Journal article
Association between Use of Prophylactic Indomethacin and the Risk for Bronchopulmonary Dysplasia in Extremely Preterm Infants
The Journal of pediatrics, Vol.186, pp.34-40.e2
07/2017
DOI: 10.1016/j.jpeds.2017.02.003
PMCID: PMC5484725
PMID: 28258737
Abstract
To assess the association between prophylactic indomethacin and bronchopulmonary dysplasia (BPD) in a recent, large cohort of extremely preterm infants.
Retrospective cohort study using prospectively collected data for infants with gestational ages < 29 weeks or birth weights of 401-1000 g born between 2008 and 2012 at participating hospitals of the National Institute of Child Health and Human Development Neonatal Research Network. Infants treated with indomethacin in the first 24 hours of life were compared with those who were not. Study outcomes were BPD, defined as use of supplemental oxygen at 36 weeks postmenstrual age among survivors to that time point, death, and the composite of death or BPD. Prespecified subgroup analyses were performed.
Prophylactic indomethacin use varied by hospital. Treatment of a patent ductus arteriosus after the first day of life was less common among 2587 infants who received prophylactic indomethacin compared with 5244 who did not (21.0% vs 36.1%, P < .001). After adjustment for potential confounders, use of prophylactic indomethacin was not associated with higher or lower odds of BPD (OR 0.89, 95% CI 0.72-1.10), death (OR 0.80, 95% CI 0.64-1.01), or death or BPD (OR 0.87, 95% CI 0.71-1.05). The only evidence of subgroup effects associated with prophylactic indomethacin were lower odds of death among infants with birth weights above the 10th percentile and those who were not treated for a patent ductus arteriosus after the first day of life.
Prophylactic indomethacin was not associated with either reduced or increased risk for BPD or death.
ClinicalTrials.gov: NCT00063063
Details
- Title: Subtitle
- Association between Use of Prophylactic Indomethacin and the Risk for Bronchopulmonary Dysplasia in Extremely Preterm Infants
- Creators
- Erik A. Jensen - Children's Hospital of PhiladelphiaEdward F. Bell - University of IowaKevin C. Dysart - Children's Hospital of PhiladelphiaJohn A. Widness - University of IowaMarie G. Gantz - Research Triangle Park FoundationBenjamin Carper - Research Triangle Park FoundationRosemary D. Higgins - National Institutes of HealthMartin Keszler - Brown UniversityMatthew M. Laughon - University of North Carolina at Chapel HillBrenda B. Poindexter - Cincinnati Children's Hospital Medical CenterBarbara J. Stoll - The University of Texas Health Science Center at San AntonioMichele C. Walsh - Case Western Reserve UniversityBarbara Schmidt - Children's Hospital of PhiladelphiaMichael S. Caplan - University of ChicagoRichard A. Polin - Columbia UniversityAbbot R. Laptook - Brown UniversityAngelita M. Hensman - Brown UniversityKristin M. Basso - Brown UniversityElisa Vieira - Brown UniversityAvroy A. Fanaroff - Case Western Reserve UniversityAnna Marie Hibbs - Case Western Reserve UniversityEmily Little - Brown UniversityNancy S. Newman - Case Western Reserve UniversityWilliam E. Truog - University of Missouri–Kansas CityHoward W. Kilbride - University of Missouri–Kansas CityEugenia K. Pallotto - University of Missouri–Kansas CityCheri Gauldin - University of Missouri–Kansas CityAnne Holmes - University of Missouri–Kansas CityKathy Johnson - University of Missouri–Kansas CityAllison Knutson - University of Missouri–Kansas CityKurt Schibler - Cincinnati Children's Hospital Medical CenterEdward F. Donovan - Cincinnati Children's Hospital Medical CenterBarbara Alexander - Cincinnati Children's Hospital Medical CenterCathy Grisby - Cincinnati Children's Hospital Medical CenterJody Hessling - Cincinnati Children's Hospital Medical CenterEstelle E. Fischer - Cincinnati Children's Hospital Medical CenterLenora D. Jackson - Cincinnati Children's Hospital Medical CenterKristin Kirker - Cincinnati Children's Hospital Medical CenterGreg Muthig - Cincinnati Children's Hospital Medical CenterRonald N. Goldberg - Duke UniversityC. Michael Cotten - Duke UniversityKimberley A. Fisher - Duke UniversityKathy J. Auten - Duke UniversityKatherine A. Foy - Duke UniversitySandra Grimes - Duke UniversityJoanne Finkle - Duke UniversityCarl L. Bose - Duke UniversityJanice Bernhardt - Duke UniversityGennie Bose - Duke UniversityDavid P. Carlton - Emory University Hospital MidtownEllen C. Hale - Emory University Hospital MidtownStephanie Wilson Archer - National Institutes of HealthGregory M. Sokol - Riley Hospital for ChildrenLeslie Dawn Wilson - Riley Hospital for ChildrenDianne E. Herron - Riley Hospital for ChildrenPablo J. Sánchez - Nationwide Children's HospitalLeif D. Nelin - Nationwide Children's HospitalSudarshan R. Jadcherla - Nationwide Children's HospitalPatricia Luzader - Nationwide Children's HospitalChristine A. Fortney - Nationwide Children's HospitalGail E. Besner - Nationwide Children's HospitalNehal A. Parikh - Nationwide Children's HospitalAbhik Das - RTI InternationalDennis Wallace - RTI InternationalJeanette O'Donnell Auman - RTI InternationalMargaret M. Crawford - RTI InternationalCarolyn M Petrie Huitema - RTI InternationalKristin M. Zaterka-Baxter - RTI InternationalKrisa P. Van Meurs - Lucile Packard Children's HospitalMarian M. Adams - Lucile Packard Children's HospitalDavid K. Stevenson - Lucile Packard Children's HospitalM. Bethany Ball - Lucile Packard Children's HospitalAndrew W. Palmquist - Lucile Packard Children's HospitalMelinda S. Proud - Lucile Packard Children's HospitalIvan D. Frantz - Tufts Children's HospitalJohn M. Fiascone - Tufts Children's HospitalBrenda L. MacKinnon - Tufts Children's HospitalEllen Nylen - Tufts Children's HospitalWaldemar A. Carlo - University of Alabama at BirminghamNamasivayam Ambalavanan - University of Alabama at BirminghamShirley S. Cosby - University of Alabama at BirminghamMonica V. Collins - University of Alabama at BirminghamUday Devaskar - University of California, Los AngelesMeena Garg - University of California, Los AngelesTeresa Chanlaw - University of California, Los AngelesRachel Geller - University of California, Los AngelesDan L. Ellsbury - University of IowaKaren J. Johnson - University of IowaDonia B. Campbell - University of IowaKristi L. Watterberg - University of New MexicoRobin K. Ohls - University of New MexicoConra Backstrom Lacy - University of New MexicoRebecca A. Montman - University of New MexicoSandra Brown - University of New MexicoTheresa Wussow - University of New MexicoCarol Hartenberger - University of New MexicoHaresh Kirpalani - Hospital of the University of PennsylvaniaSara B. DeMauro - Hospital of the University of PennsylvaniaAasma S. Chaudhary - Hospital of the University of PennsylvaniaSoraya Abbasi - Hospital of the University of PennsylvaniaToni Mancini - Hospital of the University of PennsylvaniaDara M. Cucinotta - Hospital of the University of PennsylvaniaCarl T. D'Angio - University of Rochester Medical CenterRonnie Guillet - University of Rochester Medical CenterSatyan Lakshminrusimha - University of Rochester Medical CenterAnn Marie Reynolds - University of Rochester Medical CenterLinda J. Reubens - University of Rochester Medical CenterRosemary Jensen - University of Rochester Medical CenterDeana Maffett - University of Rochester Medical CenterHolly I.M. Wadkins - University of Rochester Medical CenterMichael G. Sacilowski - University of Rochester Medical CenterAshley Williams - University of Rochester Medical CenterStephanie Guilford - University of Rochester Medical CenterCassandra A. Horihan - University of Rochester Medical CenterKathleen A. Kennedy - The University of Texas Health Science Center at HoustonJon E. Tyson - The University of Texas Health Science Center at HoustonKatrina Burson - The University of Texas Health Science Center at HoustonBeverly Foley Harris - The University of Texas Health Science Center at HoustonSharon L. Wright - The University of Texas Health Science Center at HoustonLuc P. Brion - The University of Texas Southwestern Medical CenterGeorgia E. McDavid - The University of Texas Health Science Center at HoustonLijun Chen - The University of Texas Southwestern Medical CenterPatti L. Pierce Tate - The University of Texas Health Science Center at HoustonAlicia Guzman - The University of Texas Southwestern Medical CenterMelissa H. Leps - The University of Texas Southwestern Medical CenterNancy A. Miller - The University of Texas Southwestern Medical CenterJanet S. Morgan - The University of Texas Southwestern Medical CenterDiana M. Vasil - The University of Texas Southwestern Medical CenterLizette E. Torres - The University of Texas Southwestern Medical CenterRoger G. Faix - Primary Children's HospitalBradley A. Yoder - Primary Children's HospitalKaren A. Osborne - Primary Children's HospitalKarie Bird - Primary Children's HospitalJill Burnett - Primary Children's HospitalJennifer J. Jensen - Primary Children's HospitalCynthia Spencer - Primary Children's HospitalKimberlee Weaver-Lewis - Primary Children's HospitalKaren Zanetti - Primary Children's HospitalSeetha Shankaran - University of Michigan–Ann ArborJohn Barks - Wayne State UniversityRebecca Bara - University of Michigan–Ann ArborMary Johnson - University of Michigan–Ann ArborMary Christensen - University of Michigan–Ann ArborStephanie Wiggins - University of Michigan–Ann ArborRichard A. Ehrenkranz - Boston Children's HospitalHarris Jacobs - Boston Children's HospitalPatricia Cervone - Boston Children's HospitalMonica Konstantino - Boston Children's HospitalJoAnn Poulsen - Boston Children's HospitalJanet Taft - Boston Children's HospitalNational Institute of Child Health and Human Development Neonatal Research Network
- Resource Type
- Journal article
- Publication Details
- The Journal of pediatrics, Vol.186, pp.34-40.e2
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.jpeds.2017.02.003
- PMID
- 28258737
- PMCID
- PMC5484725
- ISSN
- 0022-3476
- eISSN
- 1097-6833
- Grant note
- National Institute of Child Health and Human Development (http://dx.doi.org/10.13039/100000071)
- Language
- English
- Date published
- 07/2017
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology
- Record Identifier
- 9984353894602771
Metrics
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