Journal article
Association between a leukotriene C4 synthase gene promoter polymorphism and coronary artery calcium in young women: the Muscatine Study
Arteriosclerosis, thrombosis, and vascular biology, Vol.27(2), pp.394-399
02/2007
DOI: 10.1161/01.ATV.0000252680.72734.10
PMID: 17110605
Abstract
A majority of the recognized risk factors for atherosclerosis and the development of cardiovascular disease have been derived from the study of older populations who have already manifested clinical symptoms. If risk factors can be identified earlier in life, such as genetic variation, preventive measures may be taken before overt symptoms of pathology have manifested, and when treatments may be most effective.
In an effort to identify individuals at increased risk for cardiovascular disease, we genotyped 732 members of the Muscatine Study Longitudinal Adult Cohort for candidate genetic markers associated with several pathogenetic processes. We identified age-adjusted increased risks for coronary artery calcium (OR 4.29; 95% CI 1.78, 10.31) and increased mean carotid artery intimal-medial thickness associated with the (-444)A>C promoter polymorphism of Leukotriene C4 Synthase (LTC4S) in women. There were no similar associations in men.
LTC4S plays a key role in the process of inflammation as the rate limiting enzyme in the conversion of arachidonic acid to cysteinyl-leukotrienes, important mediators of inflammatory responses. The (-444)C variant upregulates LTC4S mRNA expression, increasing the synthesis of proinflammatory leukotrienes. Our results support genetic variation modifying inflammatory pathways as an important mechanism in the development of atherosclerosis.
Details
- Title: Subtitle
- Association between a leukotriene C4 synthase gene promoter polymorphism and coronary artery calcium in young women: the Muscatine Study
- Creators
- David M Iovannisci - Children's Hospital OaklandEdward J LammerLori SteinerSuzanne ChengLarry T MahoneyPatricia H DavisRonald M LauerTrudy L Burns
- Resource Type
- Journal article
- Publication Details
- Arteriosclerosis, thrombosis, and vascular biology, Vol.27(2), pp.394-399
- DOI
- 10.1161/01.ATV.0000252680.72734.10
- PMID
- 17110605
- ISSN
- 1079-5642
- eISSN
- 1524-4636
- Grant note
- R01 HL48050 / NHLBI NIH HHS R01 HL61357 / NHLBI NIH HHS R01 HL54730 / NHLBI NIH HHS
- Language
- English
- Date published
- 02/2007
- Academic Unit
- Neurology; Stead Family Department of Pediatrics; Epidemiology; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984363601702771
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