Journal article
Association between albuminuria and glomerular filtration rate with incident frailty
Kidney international reports, Vol.10(2), pp.489-502
02/2025
DOI: 10.1016/j.ekir.2024.11.017
PMCID: PMC11843128
PMID: 39990877
Abstract
The association between estimated glomerular filtration rate (eGFR) and albuminuria with incident frailty in generally healthy older individuals is unclear. We investigated whether baseline eGFR or urine albumin-to-creatinine ratio (UACR) are associated with incident frailty assessed using two separate methods: a modified Fried frailty phenotype (FP), and a deficit accumulation frailty index (FI).
This was a secondary analysis of the ASPirin in Reducing Events in the Elderly (ASPREE) randomised trial cohort, which enrolled independent, well, older adults aged ≥65 years in Australia and the United States. Time to incident frailty was analysed using discrete time survival analysis.
In total, 16,965 participants were included using the FP, mean age was 75.0 ± 4.5 years, median baseline eGFR was 78.6 mL/min/1.73m2 (IQR 67.6, 89.5), and the median UACR was 0.80 mg/mmol (0.50, 1.50). Data to generate the FI outcomes was available for 12,272 participants. The relationships between eGFR and both incident FP and FI were non-linear, such that an eGFR <30 or ≥95 mL/min/1.73m2 was significantly associated with an increased risk of incident frailty. For every doubling of baseline UACR, risk of incident frailty increased by 4% using the FP (HR: 1.04, 95% CI: 1.02, 1.07) and the FI (HR: 1.04, 95% CI: 1.01, 1.07).
In older, generally healthy adults, both low and high eGFRs were associated with increased risk of incident frailty. Doubling of UACR, even at low levels, was independently associated with incident frailty.
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Details
- Title: Subtitle
- Association between albuminuria and glomerular filtration rate with incident frailty
- Creators
- Elisa K. Bongetti - Monash Medical CentreAnna L. Wilkinson - Monash UniversityJames B. Wetmore - Hennepin Healthcare Research InstituteAnne M. Murray - Berman Center for Outcomes and Clinical ResearchRobyn L. Woods - Monash UniversitySara Espinoza - Cedars-Sinai Medical CenterMichael E. ErnstMichelle A. FravelSuzanne G. Orchard - Monash UniversityLe Thi Phuong Thao - Monash UniversityJoanne Ryan - Monash UniversityRory Wolfe - Monash UniversityKevan R. Polkinghorne - Monash Medical Centre
- Resource Type
- Journal article
- Publication Details
- Kidney international reports, Vol.10(2), pp.489-502
- DOI
- 10.1016/j.ekir.2024.11.017
- PMID
- 39990877
- PMCID
- PMC11843128
- NLM abbreviation
- Kidney Int Rep
- ISSN
- 2468-0249
- eISSN
- 2468-0249
- Publisher
- Elsevier Inc
- Grant note
- National Institute on AgingNational Cancer Institute at the National Institutes of Health: U01 AG029824 National Health and Medical Research Council of Australia: 334047, 1127060 Monash UniversityVictorian Cancer AgencyAustralian Government Research Training Program (RTP) Scholarship - NHMRC Dementia Research Leader Fellowship: APP1135727
This work was supported by the National Institute on Aging and the National Cancer Institute at the National Insitutes of Health (Grant U01 AG029824) , the National Health and Medical Research Council of Australia (Project Grants 334047 and 1127060) , Monash University, and the Victorian Cancer Agency. EKB was supported through an Australian Government Research Training Program (RTP) Scholarship. JR was funded by an NHMRC Dementia Research Leader Fellowship (APP1135727) .
- Language
- English
- Electronic publication date
- 11/2024
- Date published
- 02/2025
- Academic Unit
- Family and Community Medicine; Pharmacy Practice and Science
- Record Identifier
- 9984749833302771
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