Journal article
Association between ambient particulate matter exposure and semen quality in Wuhan, China
Environment international, Vol.98, pp.219-228
01/2017
DOI: 10.1016/j.envint.2016.11.013
PMID: 27866723
Abstract
Health effects of exposure to particulate matter (PM) on male reproductive health remain unclear. Only a limited number of studies have investigated the effects of PM2.5 or PM10 exposure on semen quality, and the results were largely inconsistent.
To quantitatively assess the exposure-response association between PM exposure and semen quality in Chinese men who were exposed to a wide concentration range of PM.
We investigated 1759 men from Wuhan, China, who were partners of women undergoing assisted reproductive technology procedures, and had semen examined at least once between 2013 and 2015. Individual PM2.5 and PM10 exposures during 0–90, 0–9, 10–14 and 70–90days before each semen examination (corresponding to the entire and three key periods of sperm development, respectively) were retrospectively estimated by inverse distance weighting interpolation. Linear mixed models were used to assess exposure-response relations of PM exposure with sperm concentration, count and motility.
PM2.5 exposure during 0–90 lag days ranged from 27.3 to 172.4μg/m3. It was linearly and inversely associated with sperm concentration (β: −0.20; 95% CI: −0.34, −0.07) and count (−0.22; −0.35, −0.08). For the three key exposure periods, only PM2.5 exposure during the 70–90 lag days was significantly associated with sperm concentration (−0.12; −0.22, −0.03) and count (−0.12; −0.21, −0.02). Sensitivity analyses for a subgroup (n=1146) excluding subjects with abnormal sperm concentration, count or motility yielded similar results. Compared with PM2.5, we found generally similar associations for PM10 exposure in relation to sperm concentration and count, except that the associations appeared to be nonlinear with inverted J-shaped relationships. Neither PM2.5 nor PM10 exposure was significantly associated with sperm motility (all p>0.05).
Our results suggest that ambient PM exposure during sperm development adversely affects semen quality, in particular sperm concentration and count.
•We assessed the association between PM and semen quality among 1759 Chinese men.•PM2.5 and PM10 exposures are associated with sperm concentration and count.•PM exposures are unlikely to be associated with sperm motility.•PM may decrease semen quality mainly by affecting spermatogenesis.•Our study emphasizes the urgent needs to reduce PM exposure in China.
Details
- Title: Subtitle
- Association between ambient particulate matter exposure and semen quality in Wuhan, China
- Creators
- Wei Bao - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, Iowa, USALi Wu - Reproductive Medical Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, ChinaLei Jin - Reproductive Medical Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, ChinaTingming Shi - Hubei Provincial Key Laboratory for Applied Toxicology, Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei, ChinaBing Zhang - Department of Immunization Program, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang, ChinaYun Zhou - School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, ChinaTing Zhou - School of Public Health, Wuhan University of Science and Technology, Wuhan, Hubei, ChinaHua Xiang - Wuhan Regional Climate Center, Wuhan, Hubei, ChinaYao Zuo - School of Public Health, Wuhan University of Science and Technology, Wuhan, Hubei, ChinaGuanlian Li - School of Public Health, Wuhan University of Science and Technology, Wuhan, Hubei, ChinaCheng Wang - Tongji HospitalYonggang Duan - Center of Reproductive Medicine and Andrology, Shenzhen University Hospital, Shenzhen Second People's Hospital, Shenzhen, Guangdong, ChinaZhe Peng - Hubei Provincial Key Laboratory for Applied Toxicology, Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei, ChinaXiji Huang - Hubei Provincial Key Laboratory for Applied Toxicology, Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei, ChinaHai Zhang - Hubei Provincial Key Laboratory for Applied Toxicology, Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei, ChinaTian Xu - Hubei Provincial Key Laboratory for Applied Toxicology, Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei, ChinaYonggang Li - Hubei Provincial Hospital of Integrative MedicineXinyun Pan - Hubei Provincial Key Laboratory for Applied Toxicology, Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei, ChinaYing Xia - Hubei Provincial Key Laboratory for Applied Toxicology, Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei, ChinaXun Gong - School of Economics and Management, Beijing Jiaotong University, Beijing, ChinaWeihong Chen - School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, ChinaYuewei Liu - Hubei Provincial Key Laboratory for Applied Toxicology, Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei, China
- Resource Type
- Journal article
- Publication Details
- Environment international, Vol.98, pp.219-228
- DOI
- 10.1016/j.envint.2016.11.013
- PMID
- 27866723
- NLM abbreviation
- Environ Int
- ISSN
- 0160-4120
- eISSN
- 1873-6750
- Publisher
- Elsevier Ltd
- Grant note
- name: Hubei Province Health and Family Planning Scientific Research Project, award: WJ2015MA027; DOI: 10.13039/501100001809, name: National Natural Science Foundation of China, award: 81502792; name: Zhejiang Province Project for Medical and Health Science and Technology, award: 2016152808
- Language
- English
- Date published
- 01/2017
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9983995123102771
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