Journal article
Association between an Emerging Disseminated form of Leishmaniasis and Leishmania (Viannia) braziliensis Strain Polymorphisms
Journal of clinical microbiology, Vol.50(12), pp.4028-4034
12/2012
DOI: 10.1128/JCM.02064-12
PMCID: PMC3503016
PMID: 23035200
Abstract
Leishmania
(
Viannia
)
braziliensis
causes three main types of American tegumentary leishmaniasis (ATL), localized cutaneous leishmaniasis (CL), mucosal leishmaniasis (ML), and disseminated leishmaniasis (DL). All forms are observed among individuals of Corte de Pedra, Brazil. We previously used random amplified markers to identify a multiclonal population among
L
. (
V
.)
braziliensis
isolates from ATL patients, defining parasite clades associated with different clinical syndromes. Herein we compared sequences of random amplified markers to identify genotypes of
L
. (
V
.)
braziliensis
recovered from lesions of CL, ML, and DL patients. Six polymorphic genomic loci were sequenced from 35 parasite isolates. Single-nucleotide polymorphisms (SNPs) and insertions-deletions (indels) at each locus allowed us to segregate the
L
. (
V
.)
braziliensis
population according to haplotypes. Several SNPs, indels, and haplotypes were significantly associated with an increased risk of DL. Molecular genotyping may provide markers to identify
L
. (
V
.)
braziliensis
strains likely to cause this emerging, hard-to-treat form of ATL.
Details
- Title: Subtitle
- Association between an Emerging Disseminated form of Leishmaniasis and Leishmania (Viannia) braziliensis Strain Polymorphisms
- Creators
- Adriano Queiroz - Serviço de Imunologia, Hospital Universitário Professor Edgard Santos, Universidade Federal da Bahia, Salvador, Bahia, BrazilRosana Sousa - Serviço de Imunologia, Hospital Universitário Professor Edgard Santos, Universidade Federal da Bahia, Salvador, Bahia, BrazilClaudia Heine - Serviço de Imunologia, Hospital Universitário Professor Edgard Santos, Universidade Federal da Bahia, Salvador, Bahia, BrazilManuela Cardoso - Serviço de Imunologia, Hospital Universitário Professor Edgard Santos, Universidade Federal da Bahia, Salvador, Bahia, BrazilLuiz Henrique Guimarães - Instituto Nacional de Ciência e Tecnologia—Doenças Tropicais (INCT-DT), Salvador, Bahia, BrazilPaulo Roberto Lima Machado - Instituto Nacional de Ciência e Tecnologia—Doenças Tropicais (INCT-DT), Salvador, Bahia, BrazilEdgar M Carvalho - Instituto Nacional de Ciência e Tecnologia—Doenças Tropicais (INCT-DT), Salvador, Bahia, BrazilLee W Riley - Division of Infectious Diseases, School of Public Health, University of California—Berkeley, Berkeley, California, USAMary E Wilson - Departments of Internal Medicine and Microbiology, University of Iowa and VA Medical Center, Iowa City, Iowa, USAAlbert Schriefer - Departamento de Ciências da Biointeração, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Bahia, Brazil
- Resource Type
- Journal article
- Publication Details
- Journal of clinical microbiology, Vol.50(12), pp.4028-4034
- Publisher
- American Society for Microbiology; 1752 N St., N.W., Washington, DC
- DOI
- 10.1128/JCM.02064-12
- PMID
- 23035200
- PMCID
- PMC3503016
- ISSN
- 0095-1137
- eISSN
- 1098-660X
- Language
- English
- Date published
- 12/2012
- Academic Unit
- Microbiology and Immunology; International Programs; Epidemiology; Internal Medicine
- Record Identifier
- 9984001149102771
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