Association between antecedent statin use and decreased mortality in hospitalized patients with COVID-19

Aakriti Gupta; Mahesh V Madhavan; Timothy J Poterucha; Ersilia M DeFilippis; Jessica A Hennessey; Bjorn Redfors; Christina Eckhardt; Behnood Bikdeli; Jonathan Platt; Ani Nalbandian; Pierre Elias; Matthew J Cummings; Shayan N Nouri; Matthew Lawlor; Lauren S Ranard; Jianhua Li; Claudia Boyle; Raymond Givens; Daniel Brodie; Harlan M Krumholz; Gregg W Stone; Sanjum S Sethi; Daniel Burkhoff; Nir Uriel; Allan Schwartz; Martin B Leon; Ajay J Kirtane; Elaine Y Wan; Sahil A Parikh

doi:10.1038/s41467-021-21553-1

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Association between antecedent statin use and decreased mortality in hospitalized patients with COVID-19

Journal article

Open access

Peer reviewed

Association between antecedent statin use and decreased mortality in hospitalized patients with COVID-19

Aakriti Gupta, Mahesh V Madhavan, Timothy J Poterucha, Ersilia M DeFilippis, Jessica A Hennessey, Bjorn Redfors, Christina Eckhardt, Behnood Bikdeli, Jonathan Platt, Ani Nalbandian, …

Nature communications, Vol.12(1), pp.1325-1325

02/26/2021

DOI: 10.1038/s41467-021-21553-1

PMCID: PMC7910606

PMID: 33637713

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Abstract

The coronavirus disease 2019 (COVID-19) can result in a hyperinflammatory state, leading to acute respiratory distress syndrome (ARDS), myocardial injury, and thrombotic complications, among other sequelae. Statins, which are known to have anti-inflammatory and antithrombotic properties, have been studied in the setting of other viral infections, but their benefit has not been assessed in COVID-19. This is a retrospective analysis of patients admitted with COVID-19 from February 1 through May 12 , 2020 with study period ending on June 11 , 2020. Antecedent statin use was assessed using medication information available in the electronic medical record. We constructed a multivariable logistic regression model to predict the propensity of receiving statins, adjusting for baseline sociodemographic and clinical characteristics, and outpatient medications. The primary endpoint includes in-hospital mortality within 30 days. A total of 2626 patients were admitted during the study period, of whom 951 (36.2%) were antecedent statin users. Among 1296 patients (648 statin users, 648 non-statin users) identified with 1:1 propensity-score matching, statin use is significantly associated with lower odds of the primary endpoint in the propensity-matched cohort (OR 0.47, 95% CI 0.36-0.62, p < 0.001). We conclude that antecedent statin use in patients hospitalized with COVID-19 is associated with lower inpatient mortality.

Aged

COVID-19 - drug therapy

COVID-19 - mortality

Female

Hospital Mortality

Hospitalization

Humans

Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage

Logistic Models

Male

Middle Aged

New York City - epidemiology

Propensity Score

Retrospective Studies

SARS-CoV-2 - isolation & purification

Details

Title: Subtitle: Association between antecedent statin use and decreased mortality in hospitalized patients with COVID-19
Creators: Aakriti Gupta - Yale Center for Outcomes Research and Evaluation, New Haven, CT, USA. ag3786@cumc.columbia.edu
Mahesh V Madhavan - Cardiovascular Research Foundation, New York, NY, USA
Timothy J Poterucha - NewYork-Presbyterian Hospital and the Columbia University Irving Medical Center, New York, NY, USA
Ersilia M DeFilippis - NewYork-Presbyterian Hospital and the Columbia University Irving Medical Center, New York, NY, USA
Jessica A Hennessey - NewYork-Presbyterian Hospital and the Columbia University Irving Medical Center, New York, NY, USA
Bjorn Redfors - Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden
Christina Eckhardt - NewYork-Presbyterian Hospital and the Columbia University Irving Medical Center, New York, NY, USA
Behnood Bikdeli - Yale Center for Outcomes Research and Evaluation, New Haven, CT, USA
Jonathan Platt - NewYork-Presbyterian Hospital and the Columbia University Irving Medical Center, New York, NY, USA
Ani Nalbandian - NewYork-Presbyterian Hospital and the Columbia University Irving Medical Center, New York, NY, USA
Pierre Elias - NewYork-Presbyterian Hospital and the Columbia University Irving Medical Center, New York, NY, USA
Matthew J Cummings - NewYork-Presbyterian Hospital and the Columbia University Irving Medical Center, New York, NY, USA
Shayan N Nouri - NewYork-Presbyterian Hospital and the Columbia University Irving Medical Center, New York, NY, USA
Matthew Lawlor - NewYork-Presbyterian Hospital and the Columbia University Irving Medical Center, New York, NY, USA
Lauren S Ranard - NewYork-Presbyterian Hospital and the Columbia University Irving Medical Center, New York, NY, USA
Jianhua Li - NewYork-Presbyterian Hospital and the Columbia University Irving Medical Center, New York, NY, USA
Claudia Boyle - NewYork-Presbyterian Hospital and the Columbia University Irving Medical Center, New York, NY, USA
Raymond Givens - NewYork-Presbyterian Hospital and the Columbia University Irving Medical Center, New York, NY, USA
Daniel Brodie - NewYork-Presbyterian Hospital and the Columbia University Irving Medical Center, New York, NY, USA
Harlan M Krumholz - Yale Center for Outcomes Research and Evaluation, New Haven, CT, USA
Gregg W Stone - The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Sanjum S Sethi - NewYork-Presbyterian Hospital and the Columbia University Irving Medical Center, New York, NY, USA
Daniel Burkhoff - Cardiovascular Research Foundation, New York, NY, USA
Nir Uriel - NewYork-Presbyterian Hospital and the Columbia University Irving Medical Center, New York, NY, USA
Allan Schwartz - NewYork-Presbyterian Hospital and the Columbia University Irving Medical Center, New York, NY, USA
Martin B Leon - Cardiovascular Research Foundation, New York, NY, USA
Ajay J Kirtane - Cardiovascular Research Foundation, New York, NY, USA
Elaine Y Wan - NewYork-Presbyterian Hospital and the Columbia University Irving Medical Center, New York, NY, USA. eyw2003@cumc.columbia.edu
Sahil A Parikh - Cardiovascular Research Foundation, New York, NY, USA
Resource Type: Journal article
Publication Details: Nature communications, Vol.12(1), pp.1325-1325
DOI: 10.1038/s41467-021-21553-1
PMID: 33637713
PMCID: PMC7910606
NLM abbreviation: Nat Commun
ISSN: 2041-1723
eISSN: 2041-1723
Language: English
Date published: 02/26/2021
Academic Unit: Epidemiology; Injury Prevention Research Center
Record Identifier: 9984214818002771

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