Association between body composition and hip fractures in older women with physical frailty

Oleg Zaslavsky; Wenjun Li; Scott Going; Mridul Datta; Linda Snetselaar; Shira Zelber-Sagi

doi:10.1111/ggi.12798

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$Association between body composition and hip fractures in older women with physical frailty$

Journal article

Peer reviewed

Association between body composition and hip fractures in older women with physical frailty

Oleg Zaslavsky, Wenjun Li, Scott Going, Mridul Datta, Linda Snetselaar and Shira Zelber-Sagi

Geriatrics & gerontology international, Vol.17(6), pp.898-904

06/2017

DOI: 10.1111/ggi.12798

PMCID: PMC5104679

PMID: 27164296

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Abstract

We sought to determine the extent to which higher lean and fat mass as measured by dual X-ray absorptiometry in older adults with frailty are related to total hip bone mass density (BMD) index and the rate of hip fractures. The data are from the Women's Health Initiative Observational Study. We identified 872 participants aged ≥65 years with body composition measures and positive frailty. Frailty was determined using modified Fried's criteria. Linear and Cox regressions were used to model study outcomes. During the follow-up period, 5.6% patients (n = 49) had sustained a hip fracture. Body composition indexes were associated with total hip BMD (P < 0.001 for all). In models adjusted for age, ethnicity, smoking, history of fractures, recurrent falls, number of frailty criteria and corresponding lean mass, the hazard ratio for hip fracture per 1 kg/m increase in fat mass was 0.73 (95% confidence interval 0.60-0.88) for appendicular compartment, 0.76 (95% confidence interval 0.65-0.89) for trunk and 0.84 (95% confidence interval 0.77-0.93) for whole-body fat mass. The hazard ratio for hip fracture per 1 kg/m increase in appendicular lean mass was 0.63 (95% confidence interval 0.46-0.88). However, after final adjustment for total hip BMD, the only index that remained statistically significant was whole-body fat mass (P for trend = 0.04). We showed that in frail older women, higher fat and lean mass was associated with reduced hip-fracture rates. Higher whole-body adiposity, however, was also associated with lower hip-fracture rate independent of total hip BMD. The present results confirm the importance of weight maintenance in frail populations. Geriatr Gerontol Int 2017; 17: 898-904.

Body Composition

Body Mass Index

Bone Density

Humans

Risk Factors

Aged, 80 and over

Female

Aged

Hip Fractures - epidemiology

Absorptiometry, Photon

Cohort Studies

Frailty - complications

Details

Title: Subtitle: Association between body composition and hip fractures in older women with physical frailty
Creators: Oleg Zaslavsky - Department of Biobehavioral Nursing and Health Systems, University of Washington, Washington, USA
Wenjun Li - Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
Scott Going - College Agriculture and Life Sciences, University of Arizona, Tucson, Arizona, USA
Mridul Datta - Department of Nutrition Science, Purdue University, West Lafayette, Indiana, USA
Linda Snetselaar - Department of Epidemiology, University of Iowa, Iowa City, Iowa, USA
Shira Zelber-Sagi - Faculty of Health Sciences and Social Welfare, University of Haifa, Israel
Resource Type: Journal article
Publication Details: Geriatrics & gerontology international, Vol.17(6), pp.898-904
DOI: 10.1111/ggi.12798
PMID: 27164296
PMCID: PMC5104679
NLM abbreviation: Geriatr Gerontol Int
ISSN: 1447-0594
eISSN: 1447-0594
Publisher: Japan
Grant note: N01WH22110 / WHI NIH HHS
Language: English
Date published: 06/2017
Academic Unit: Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
Record Identifier: 9983995119502771

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