Association between brain-derived neurotrophic factor Val66Met gene polymorphism and progressive brain volume changes in schizophrenia

Beng-Choon Ho; Nancy C Andreasen; Jeffrey D Dawson; Thomas H Wassink

doi:10.1176/appi.ajp.2007.05111903

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Association between brain-derived neurotrophic factor Val66Met gene polymorphism and progressive brain volume changes in schizophrenia

Journal article

Open access

Peer reviewed

Association between brain-derived neurotrophic factor Val66Met gene polymorphism and progressive brain volume changes in schizophrenia

Beng-Choon Ho, Nancy C Andreasen, Jeffrey D Dawson and Thomas H Wassink

The American journal of psychiatry, Vol.164(12), pp.1890-1899

12/2007

DOI: 10.1176/appi.ajp.2007.05111903

PMCID: PMC3062255

PMID: 18056245

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https://www.ncbi.nlm.nih.gov/pmc/articles/3062255View

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Abstract

Factors underlying progressive brain volume changes in schizophrenia remain poorly understood. The authors investigated whether a gene polymorphism influencing neuroplasticity may contribute to longitudinal brain volume alterations. High-resolution magnetic resonance (MR) images of the whole brain were obtained for 119 patients with recent-onset schizophrenia spectrum disorders. Changes in brain volumes over an average of 3 years were compared between brain-derived neurotrophic factor (BDNF) val66met genotype groupings. Exploratory analyses were conducted to examine relationships between antipsychotic treatment and brain volume changes as well as the effects of BDNF genotype on changes in cognition and symptoms. Significant genotype effects were observed on within-subject changes in volumes of frontal lobe gray matter, lateral ventricles, and sulcal CSF. Met allele carriers had significantly greater reductions in frontal gray matter volume, with reciprocal volume increases in the lateral ventricles and sulcal (especially frontal and temporal) CSF than Val homozygous patients. Independent of BDNF genotype, more antipsychotic exposure between MRI scans correlated with greater volume reductions in frontal gray matter, particularly among patients who were initially treatment naive. There were no statistically significant genotype effects on within-subject changes in cognition or symptoms. BDNF(Met) variant may be one of several factors affecting progressive brain volume changes in schizophrenia.

Brain-Derived Neurotrophic Factor - genetics

Humans

Atrophy - pathology

Male

Schizophrenia - pathology

Schizophrenic Psychology

Genetic Variation

Neuronal Plasticity - genetics

Schizophrenia - genetics

Antipsychotic Agents - therapeutic use

Magnetic Resonance Imaging - statistics & numerical data

Adult

Female

Cognition Disorders - psychology

Severity of Illness Index

Genotype

Neuropsychological Tests

Cognition Disorders - diagnosis

Brain - pathology

Polymorphism, Genetic - genetics

Valine - genetics

Schizophrenia - drug therapy

Longitudinal Studies

Frontal Lobe - pathology

Methionine - genetics

Details

Title: Subtitle: Association between brain-derived neurotrophic factor Val66Met gene polymorphism and progressive brain volume changes in schizophrenia
Creators: Beng-Choon Ho - Department of Psychiatry, University of Iowa College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA. beng-ho@uiowa.edu
Nancy C Andreasen
Jeffrey D Dawson
Thomas H Wassink
Resource Type: Journal article
Publication Details: The American journal of psychiatry, Vol.164(12), pp.1890-1899
DOI: 10.1176/appi.ajp.2007.05111903
PMID: 18056245
PMCID: PMC3062255
NLM abbreviation: Am J Psychiatry
ISSN: 0002-953X
eISSN: 1535-7228
Publisher: United States
Grant note: MH 43271 / NIMH NIH HHS MH 31593 / NIMH NIH HHS R01 MH031593 / NIMH NIH HHS R01 MH040856 / NIMH NIH HHS MH 68380 / NIMH NIH HHS MH 40856 / NIMH NIH HHS R37 MH031593 / NIMH NIH HHS K23 MH068380 / NIMH NIH HHS K23 MH068380-01A2 / NIMH NIH HHS
Language: English
Date published: 12/2007
Academic Unit: Public Health Administration; Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Biostatistics
Record Identifier: 9983997329502771

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