Journal article
Association between cardiovascular care and neurodevelopmental outcomes in infants with neonatal encephalopathy and hemodynamic instability
Journal of perinatology, Vol.45(8), pp.1073-1080
08/2025
DOI: 10.1038/s41372-025-02230-3
PMID: 39962327
Abstract
To analyze the approach to cardiovascular care and long-term outcomes in infants undergoing hypothermia for neonatal encephalopathy (NE).
This is a retrospective cohort study of 152 infants with NE [SickKids Hospital (Center A, n = 74) or Semmelweis University (Center B, n = 78)], who developed hypotension and underwent neonatal follow-up. Primary outcome was defined as death or neurodevelopmental impairment (<70 on Bayley-II or <85 points on Bayley-III test).
The presence of hypoxic injury in the brain MRI increased the odds of adverse outcome by 10.5 fold. In addition, for every 24 h increase in the duration of cardiovascular support the odds of adverse outcome increased by 12%. In a subgroup of patients with detailed echocardiography evaluation lower tricuspid annulus plane systolic excursion was noted in the non-survivors.
Hypoxic brain injury and longer cardiovascular therapy are independently associated with the adverse long-term outcome in patients with NE.
Details
- Title: Subtitle
- Association between cardiovascular care and neurodevelopmental outcomes in infants with neonatal encephalopathy and hemodynamic instability
- Creators
- Kata Kovacs - Semmelweis UniversityRegan E Giesinger - University of IowaZsuzsanna Varga - Semmelweis UniversityMiklos Szabo - Semmelweis UniversityAgnes Jermendy - Semmelweis UniversityPatrick J McNamara - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of perinatology, Vol.45(8), pp.1073-1080
- DOI
- 10.1038/s41372-025-02230-3
- PMID
- 39962327
- NLM abbreviation
- J Perinatol
- ISSN
- 0743-8346
- eISSN
- 1476-5543
- Publisher
- SPRINGERNATURE
- Grant note
- OTKA PD 142288 / Országos Tudományos Kutatási Alapprogramok (Hungarian Scientific Research Fund)
- Language
- English
- Electronic publication date
- 02/17/2025
- Date published
- 08/2025
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology; Internal Medicine
- Record Identifier
- 9984790994202771
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