Association between heme oxygenase-1 gene promoter polymorphisms and type 2 diabetes mellitus: a HuGE review and meta-analysis

Wei Bao; Fangfang Song; Xiangyang Li; Shuang Rong; Wei Yang; Di Wang; Jiqu Xu; Juan Fu; Yanting Zhao; Liegang Liu

doi:10.1093/aje/kwq162

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Association between heme oxygenase-1 gene promoter polymorphisms and type 2 diabetes mellitus: a HuGE review and meta-analysis

Journal article

Open access

Peer reviewed

Association between heme oxygenase-1 gene promoter polymorphisms and type 2 diabetes mellitus: a HuGE review and meta-analysis

Wei Bao, Fangfang Song, Xiangyang Li, Shuang Rong, Wei Yang, Di Wang, Jiqu Xu, Juan Fu, Yanting Zhao and Liegang Liu

American journal of epidemiology, Vol.172(6), pp.631-636

09/15/2010

DOI: 10.1093/aje/kwq162

PMID: 20682519

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Abstract

Several studies have recently focused on the association between heme oxygenase-1 (HMOX1) gene promoter polymorphisms and susceptibility to type 2 diabetes mellitus; however, results have been conflicting. This systematic Human Genome Epidemiology review and meta-analysis was undertaken to integrate previous findings and summarize the effect size of the association of HMOX1 gene promoter polymorphisms with susceptibility to type 2 diabetes. The authors retrieved all studies matched to search terms from the PubMed/MEDLINE, EMBASE, and ISI Web of Science databases that had been published through December 31, 2009. The articles were then checked independently by 2 investigators according to the eligibility and exclusion criteria. For all alleles and genotypes, odds ratios were pooled using either fixed-effects or random-effects models. An increased odds ratio for type 2 diabetes was observed in persons with the (GT)(n) L (long) allele as compared with those with the (GT)(n) S (short) allele (odds ratio = 1.12, 95% confidence interval: 1.02, 1.24; P = 0.02). Furthermore, the diabetes odds ratio for persons with the LL genotype, versus those with the SS genotype, was significantly increased (odds ratio = 1.25, 95% confidence interval: 1.04, 1.50; P = 0.02). Persons carrying longer (GT)(n) repeats in the HMOX1 gene promoter may have a higher risk of type 2 diabetes.

Heme Oxygenase-1 - genetics

Promoter Regions, Genetic

Genetic Predisposition to Disease

Diabetes Mellitus, Type 2 - genetics

Humans

Genotype

Polymorphism, Single Nucleotide

Microsatellite Repeats

Details

Title: Subtitle: Association between heme oxygenase-1 gene promoter polymorphisms and type 2 diabetes mellitus: a HuGE review and meta-analysis
Creators: Wei Bao - Department of Nutrition and Food Hygiene and Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China
Fangfang Song
Xiangyang Li - Huazhong University of Science and Technology
Shuang Rong
Wei Yang
Di Wang
Jiqu Xu
Juan Fu
Yanting Zhao
Liegang Liu
Resource Type: Journal article
Publication Details: American journal of epidemiology, Vol.172(6), pp.631-636
DOI: 10.1093/aje/kwq162
PMID: 20682519
NLM abbreviation: Am J Epidemiol
ISSN: 1476-6256
eISSN: 1476-6256
Publisher: United States
Language: English
Date published: 09/15/2010
Academic Unit: Epidemiology; Fraternal Order of Eagles Diabetes Research Center
Record Identifier: 9983995005802771

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