Journal article
Association between medication-induced xerostomia and orofacial pain: a systematic review.
Quintessence international (Berlin, Germany : 1985), Vol.54(8), pp.658-670
09/19/2023
DOI: 10.3290/j.qi.b4154345
PMCID: PMC10527150
PMID: 37305957
Abstract
Objective: Xerostomia (or oral dryness) is most commonly caused by medications that affect saliva secretion, and is often accompanied by symptoms of orofacial pain. Medication-induced xerostomia may or may not be associated with objectively demonstrable hyposalivation. The present study attempted to systematically identify an association between medication-induced xerostomia and orofacial pain.
Method and materials: A systematic search was conducted using the following databases: WoS, PubMed, SCOPUS, and MEDLINE. The search terms used were: xerostomia OR “dry mouth” AND medication AND (“oral pain” OR “orofacial pain” OR “craniofacial pain” OR “burning mouth” OR “glossodynia”) NOT Sjögren’s NOT cancer. Inclusion criteria were medication-induced xerostomia and reported symptoms of orofacial pain. Four researchers performed the selection process and quality assessment and two researchers conducted data extraction.
Results: Seven studies with a total of 1,029 patients were included. These studies were conducted between 2009 and 2022 and consisted of cross-sectional studies, case-control studies, and one randomized crossover trial. The studies consisted of a total of 1,029 participants. All studies included male and female participants whose mean ages ranged from 43 to 100 years.
Conclusions: A positive association was found between medication-induced xerostomia and orofacial pain. No associations were found between salivary flow measurements (hyposalivation) and medication use. Future research should focus on saliva flow measurements, standardized assessment of medication-induced xerostomia, as well as the inclusion of accompanying orofacial pain diagnosis in the medical history to allow for higher level of evidence in establishing reliable predictors of medication-induced oral health damage to facilitate clinical prevention and management.
Details
- Title: Subtitle
- Association between medication-induced xerostomia and orofacial pain: a systematic review.
- Creators
- Divya Kohli - Nova Southeastern UniversityNikkita Madhu - University of IowaOlga A. Korczeniewska - Center for Orofacial Pain and Temporomandibular Disorders, Department of Diagnostic Sciences, Rutgers School of Dental Medicine, Rutgers, The State University of New Jersey, Newark, New JerseyTal Eliav - Ben-Gurion University of the NegevSzilvia Arany - University of Rochester
- Resource Type
- Journal article
- Publication Details
- Quintessence international (Berlin, Germany : 1985), Vol.54(8), pp.658-670
- DOI
- 10.3290/j.qi.b4154345
- PMID
- 37305957
- PMCID
- PMC10527150
- ISSN
- 0033-6572
- eISSN
- 1936-7163
- Language
- English
- Date published
- 09/19/2023
- Academic Unit
- Prosthodontics
- Record Identifier
- 9984655346602771
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