Journal article
Association between plasma concentrations of elaidic acid, a major trans fatty acid, and depression in a nationally representative sample of U.S. adults
Journal of affective disorders, Vol.249, pp.301-306
04/15/2019
DOI: 10.1016/j.jad.2019.02.032
PMID: 30797122
Abstract
•Accumulating epidemiological evidence indicates that diet plays an important but neglected role in mental health.•Plasma elaidic acid concentrations, a major trans fatty acid, was associated with higher risk of depression.•A positive but non-significant association of depressive symptoms was observed for total TFAs, linolelaidic acid, palmitelaidic acid, and vaccenic acid.
Previous studies on health effects of trans fatty acids (TFA) have focused mainly on cardiovascular health. Little is known about the association of TFA with brain or mental health. In this study, we examined the associations of objectively-measured plasma TFA concentrations with depression in a large population-based cross-sectional study among U.S. adults.
We included 2136 non-pregnant participants aged 20 years or older from the National Health and Nutrition Examination Survey 2009–2010. Four major TFAs, including palmitelaidic acid (C16:1n-7t), elaidic acid (C18:1n-9t), vaccenic acid (C18:1n-7t), and linoelaidic acid (C18:2n-6t, 9t), were measured in fasting plasma using gas chromatography/mass spectrometry. Depressive symptoms were assessed using the validated Patient Health Questionnaire-9.
Participants with depressive symptoms had a higher plasma concentration of total TFA compared with those without depressive symptoms (6.6 vs 6.0 μmol/g lipids, P = 0.046). After adjustment for other major risk factors, the odds ratio (OR) of depressive symptoms comparing the highest with lowest tertile of TFAs was 1.44 (95% CI, 0.86–2.39) for total TFAs (P for trend 0.15). For each individual type of TFA, the corresponding OR was 1.78 (1.03–3.07) for elaidic acid (P for trend 0.049), 1.23 (0.76–2.00) for linoelaidic acid (P for trend 0.37), 1.19 (0.75–1.87) for palmitelaidic acid (P for trend 0.46), and 1.20 (0.75–1.94) for vaccenic acid (P for trend 0.43).
The cross-sectional study design limited causal inferences of the findings.
In a nationally representative population, plasma elaidic acid, a major trans fatty acid, was positively associated with depressive symptoms in adults. A positive but non-significant association of depressive symptoms was observed for total TFAs, linolelaidic acid, palmitelaidic acid, and vaccenic acid.
Details
- Title: Subtitle
- Association between plasma concentrations of elaidic acid, a major trans fatty acid, and depression in a nationally representative sample of U.S. adults
- Creators
- Buyun Liu - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA 52242, USAYangbo Sun - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA 52242, USAGuifeng Xu - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA 52242, USAYang Du - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA 52242, USAAvanthi S Ajjarapu - Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USALinda G Snetselaar - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA 52242, USAWei Bao - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- Journal of affective disorders, Vol.249, pp.301-306
- DOI
- 10.1016/j.jad.2019.02.032
- PMID
- 30797122
- NLM abbreviation
- J Affect Disord
- ISSN
- 0165-0327
- eISSN
- 1573-2517
- Publisher
- Elsevier B.V
- Language
- English
- Date published
- 04/15/2019
- Academic Unit
- Stead Family Department of Pediatrics; Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9983995011902771
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