Journal article
Association between plasma strontium, a bone-seeking element, and type 2 diabetes mellitus
Clinical nutrition (Edinburgh, Scotland), Vol.39(7), pp.2151-2157
07/2020
DOI: 10.1016/j.clnu.2019.08.033
PMID: 31540775
Abstract
Drinking water and food are the major sources of strontium in human. Strontium is essential for bone metabolism, while its role in glucose and lipid metabolism is largely unknown. We aimed to investigate the association of strontium, a bone-seeking element, with type 2 diabetes mellitus (T2DM) and impaired glucose regulation (IGR) and to further explore the potential mechanisms.
The case-control study included 1448 newly diagnosed T2DM patients, 782 IGR patients, and 2230 matched controls with normal glucose tolerance. Plasma strontium and other plasma minerals were quantified via inductively coupled plasma mass spectrometry. Multivariable logistic regression analysis was used to evaluate the independent associations between plasma strontium and T2DM and IGR.
Plasma strontium was inversely associated with T2DM and IGR. After adjustment for sociodemographic, lifestyle factors, and multiple plasma metals, the odds ratios (95% confidence intervals) of T2DM and IGR were 0.45 (0.35–0.57) and 0.55 (0.43–0.71), respectively, comparing the highest to the lowest quartile of plasma strontium levels. In spline analysis, the odds of T2DM and IGR decreased remarkably with increasing strontium concentration and followed by a plateau. Additionally, plasma strontium was negatively associated with total cholesterol, low density lipoprotein cholesterol, and lipid peroxidation (plasma malondialdehyde level).
The current study indicated that higher plasma strontium concentration was associated with lower odds of T2DM and IGR. Further studies are warranted to confirm these findings and to clarify the underlying mechanisms.
Details
- Title: Subtitle
- Association between plasma strontium, a bone-seeking element, and type 2 diabetes mellitus
- Creators
- Liangkai Chen - Huazhong University of Science and TechnologyQianqian Guo - Huazhong University of Science and TechnologyQiang Wang - Huazhong University of Science and TechnologyCheng Luo - Huazhong University of Science and TechnologySijing Chen - Huazhong University of Science and TechnologySheng Wen - Hubei Provincial Center for Disease Control and PreventionAijun Tan - Zhuhai Center for Disease Control and Prevention, Zhuhai, China;Wei Yang - Huazhong University of Science and TechnologyWei Bao - University of IowaFrank B. Hu - Harvard UniversityLiegang Liu - Huazhong University of Science and Technology
- Resource Type
- Journal article
- Publication Details
- Clinical nutrition (Edinburgh, Scotland), Vol.39(7), pp.2151-2157
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/j.clnu.2019.08.033
- PMID
- 31540775
- ISSN
- 0261-5614
- eISSN
- 1532-1983
- Grant note
- DOI: 10.13039/501100001809, name: National Natural Science Foundation of China
- Language
- English
- Date published
- 07/2020
- Academic Unit
- Epidemiology
- Record Identifier
- 9984364370502771
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