Journal article
Association between plasma trans-fatty acid concentrations and diabetes in a nationally representative sample of US adults
Journal of diabetes, Vol.10(8), pp.653-664
08/2018
DOI: 10.1111/1753-0407.12652
PMCID: PMC6093805
PMID: 29446544
Abstract
A diet high in trans-fatty acids (TFA) induces insulin resistance in rodent models and primates. However, previous epidemiological studies on the association between TFAs, based primarily on self-reported intake from the diet, and diabetes in humans have yielded conflicting results. Herein we examined the associations of objectively measured plasma TFA concentrations with diabetes in a large population-based study among US adults.
We included 3801 participants aged ≥20 years from the National Health and Nutrition Examination Survey 1999-2000 and 2009-10. Four major TFAs, namely palmitelaidic acid (C16:1 n-7t), elaidic acid (C18:1 n-9t), vaccenic acid (C18:1 n-7t), and linolelaidic acid (C18:2 n-6t, 9t), were measured in fasting plasma using gas chromatography-mass spectrometry. Diabetes was defined by self-reported physician diagnosis, plasma fasting glucose ≥126 mg/dL, or HbA1c ≥6.5%.
After adjustment for other major risk factors, the odds ratios (95% confidence intervals) of diabetes comparing the highest with lowest quintile of plasma TFAs was 2.19 (1.27-3.79) for total TFAs (P
= 0.01), 2.34 (1.48-3.72) for elaidic acid (P
= 0.0004), 1.33 (0.82-2.15) for linolelaidic acid (P
= 0.18), 1.58 (0.97-2.58) for palmitelaidic acid (P
= 0.02), and 1.64 (0.95-2.84) for vaccenic acid (P
= 0.08). In addition, total TFAs, elaidic acid, palmitelaidic acid, and vaccenic acid were significantly associated with fasting glucose, fasting insulin, the insulin resistance index, and HbA1c.
In a nationally representative population, plasma TFAs, in particular elaidic acid, were positively associated with diabetes and biomarkers of glucose metabolism.
Details
- Title: Subtitle
- Association between plasma trans-fatty acid concentrations and diabetes in a nationally representative sample of US adults
- Creators
- Buyun Liu - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, Iowa, USAYangbo Sun - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, Iowa, USALinda G Snetselaar - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, Iowa, USAQi Sun - Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USAQuanhe Yang - Division for Heart Disease and Stroke Prevention, National Center for Chronic Disease and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USAZefeng Zhang - Division for Heart Disease and Stroke Prevention, National Center for Chronic Disease and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USALiegang Liu - Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Wuhan, ChinaFrank B Hu - Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USAWei Bao - Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, Iowa, USA
- Resource Type
- Journal article
- Publication Details
- Journal of diabetes, Vol.10(8), pp.653-664
- DOI
- 10.1111/1753-0407.12652
- PMID
- 29446544
- PMCID
- PMC6093805
- NLM abbreviation
- J Diabetes
- ISSN
- 1753-0407
- eISSN
- 1753-0407
- Publisher
- Australia
- Grant note
- P30 ES005605 / NIEHS NIH HHS R21 HD091458 / NICHD NIH HHS
- Language
- English
- Date published
- 08/2018
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9983995008902771
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