Journal article
Association between prepregnancy body mass index and congenital heart defects
American journal of obstetrics and gynecology, Vol.202(1), pp.51.e1-51.e10
2010
DOI: 10.1016/j.ajog.2009.08.005
PMID: 19796755
Abstract
The purpose of this study was to examine associations between prepregnancy body mass index (BMI) and congenital heart defects (CHDs).
These analyses included case infants with CHDs (n = 6440) and liveborn control infants without birth defects (n = 5673) enrolled in the National Birth Defects Prevention Study (1997-2004).
Adjusted odds ratios for all CHDs combined were 1.16 (95% confidence interval [CI], 1.05–1.29), 1.15 (95% CI, 1.00–1.32), and 1.31 (95% CI, 1.11–1.56) for overweight status, moderate obesity, and severe obesity, respectively. Phenotypes associated with elevated BMI (≥25.0 kg/m
2) were conotruncal defects (tetralogy of Fallot), total anomalous pulmonary venous return, hypoplastic left heart syndrome, right ventricular outflow tract (RVOT) defects (pulmonary valve stenosis), and septal defects (secundum atrial septal defect).
These results corroborated those of previous studies and suggested new associations between obesity and conotruncal defects and RVOT defects.
Details
- Title: Subtitle
- Association between prepregnancy body mass index and congenital heart defects
- Creators
- Suzanne M Gilboa - National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GAAdolfo Correa - National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GALorenzo D Botto - Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UTSonja A Rasmussen - National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GAD. Kim Waller - School of Public Health, University of Texas Health Sciences Center at Houston, Houston, TXCharlotte A Hobbs - Department of Pediatrics, Birth Defects Research Section, University of Arkansas for Medical Sciences and Arkansas Children's Hospital Research Institute, Little Rock, ARMario A Cleves - Department of Pediatrics, Birth Defects Research Section, University of Arkansas for Medical Sciences and Arkansas Children's Hospital Research Institute, Little Rock, ARTiffany J Riehle-Colarusso - National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GANational Birth Defects Prevention Study
- Contributors
- Paul A Romitti (Contributor) - University of Iowa, Epidemiology
- Resource Type
- Journal article
- Publication Details
- American journal of obstetrics and gynecology, Vol.202(1), pp.51.e1-51.e10
- DOI
- 10.1016/j.ajog.2009.08.005
- PMID
- 19796755
- NLM abbreviation
- Am J Obstet Gynecol
- ISSN
- 0002-9378
- eISSN
- 1097-6868
- Publisher
- Mosby, Inc
- Language
- English
- Date published
- 2010
- Academic Unit
- Epidemiology; Biostatistics
- Record Identifier
- 9984214791002771
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