Association between radiographic features of knee osteoarthritis and pain: results from two cohort studies

Tuhina Neogi; David Felson; Jingbo Niu; Michael Nevitt; Cora E Lewis; Piran Aliabadi; Burt Sack; James Torner; Lawrence Bradley; Yuqing Zhang

doi:10.1136/bmj.b2844

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Association between radiographic features of knee osteoarthritis and pain: results from two cohort studies

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Association between radiographic features of knee osteoarthritis and pain: results from two cohort studies

Tuhina Neogi, David Felson, Jingbo Niu, Michael Nevitt, Cora E Lewis, Piran Aliabadi, Burt Sack, James Torner, Lawrence Bradley and Yuqing Zhang

BMJ (Clinical research ed.), Vol.339(7719), pp.b2844-501

08/21/2009

DOI: 10.1136/bmj.b2844

PMCID: PMC2730438

PMID: 19700505

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Abstract

To examine the relation of radiographic features of osteoarthritis to knee pain in people with knees discordant for knee pain in two cohorts. Within person, knee matched, case-control study. Participants in the Multicenter Osteoarthritis (MOST) and Framingham Osteoarthritis studies who had knee radiographs and assessments of knee pain. Association of each pain measure (frequency, consistency, and severity) with radiographic osteoarthritis, as assessed by Kellgren and Lawrence grade (0-4) and osteophyte and joint space narrowing grades (0-3) among matched sets of two knees within individual participants whose knees were discordant for pain status. 696 people from MOST and 336 people from Framingham were included. Kellgren and Lawrence grades were strongly associated with frequent knee pain-for example, for Kellgren and Lawrence grade 4 v grade 0 the odds ratio for pain was 151 (95% confidence interval 43 to 526) in MOST and 73 (16 to 331) in Framingham (both P<0.001 for trend). Similar results were also seen for the relation of Kellgren and Lawrence scores to consistency and severity of knee pain. Joint space narrowing was more strongly associated with each pain measure than were osteophytes. Using a method that minimises between person confounding, this study found that radiographic osteoarthritis and individual radiographic features of osteoarthritis were strongly associated with knee pain.

Arthralgia - etiology

Arthralgia - pathology

Prognosis

Humans

Middle Aged

Arthralgia - diagnostic imaging

Male

Osteoarthritis, Knee - diagnostic imaging

Case-Control Studies

Radiography

Osteoarthritis, Knee - complications

Osteoarthritis, Knee - pathology

Aged, 80 and over

Female

Aged

Pain Measurement

Cohort Studies

Details

Title: Subtitle: Association between radiographic features of knee osteoarthritis and pain: results from two cohort studies
Creators: Tuhina Neogi - Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, 650 Albany Street, Boston, MA 02118, USA. tneogi@bu.edu
David Felson
Jingbo Niu
Michael Nevitt
Cora E Lewis
Piran Aliabadi
Burt Sack
James Torner
Lawrence Bradley
Yuqing Zhang
Resource Type: Journal article
Publication Details: BMJ (Clinical research ed.), Vol.339(7719), pp.b2844-501
DOI: 10.1136/bmj.b2844
PMID: 19700505
PMCID: PMC2730438
NLM abbreviation: BMJ
ISSN: 1756-1833
eISSN: 1756-1833
Publisher: England
Grant note: U01 AG018947 / NIA NIH HHS U01 AG018832 / NIA NIH HHS AR47785 / NIAMS NIH HHS U01 AG18832 / NIA NIH HHS AG18393 / NIA NIH HHS U01 AG019069 / NIA NIH HHS U01 AG18820 / NIA NIH HHS P60 AR047785 / NIAMS NIH HHS K23 AR055127 / NIAMS NIH HHS U01AG18947 / NIA NIH HHS N01-HC-25195 / NHLBI NIH HHS U01 AG19069 / NIA NIH HHS U01 AG018820 / NIA NIH HHS
Language: English
Date published: 08/21/2009
Academic Unit: Epidemiology; Surgery; Injury Prevention Research Center; Neurosurgery
Record Identifier: 9983995038102771

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