Journal article
Association between serum selenium concentrations and learning disability in a nationally representative sample of U.S. children
Nutritional neuroscience, Vol.25(7), pp.1558-1564
2022
DOI: 10.1080/1028415X.2021.1879541
PMID: 33939947
Abstract
Oxidative stress has been implicated in the pathogenesis of neurodevelopmental disorders. As an anti-oxidative agent, selenium plays an important role in human health. However, the relationship between selenium status and learning disability (LD), a common neurodevelopmental disorder, is unknown.
To examine the association between serum selenium concentrations and learning disability.
Nationwide, population-based, cross-sectional study.
Children aged 4-11 years who have available data on serum selenium concentrations and LD (N = 1,076) from the U.S. National Health and Nutrition Examination Survey 1999-2000.
Serum selenium levels were measured using atomic absorption spectrometry.
Diagnosis of LD was reported by the children's parents.
Logistic regression models with survey weights were conducted adjusting for age, race/ethnicity, family income, total energy intake, body mass index, and serum cotinine levels.
In this study, 8.2% (95% confidence interval [CI] 5.2%-11.2%) of children had a diagnosis of LD. Serum selenium concentration was lower among children with LD than those without LD (geometric mean ± standard error, 107.7 ± 2.7 ng/mL vs. 112.8 ± 1.0 ng/mL, P for difference = 0.08). The adjusted odds ratio (OR) of LD comparing the highest with lowest tertile of serum selenium concentrations was 0.39 (95% CI 0.19-0.82). Each 10 ng/mL increment in serum selenium concentrations was associated with 31% (OR 0.69, 95% CI 0.51-0.93) lower odds of LD.
Higher serum selenium concentration was associated with a lower risk of LD in U.S. children. The causal relationship between selenium and LD and the underlying mechanisms warrant further investigation.
Details
- Title: Subtitle
- Association between serum selenium concentrations and learning disability in a nationally representative sample of U.S. children
- Creators
- Buyun Liu - College of Public Health, University of IowaGuifeng Xu - University of Iowa Stead Family Children's HospitalWenhan Yang - School of Public Health, Sun Yat-sen UniversityLane Strathearn - University of Iowa Carver College of MedicineLinda G Snetselaar - College of Public Health, University of IowaWei Bao - College of Public Health, University of Iowa
- Resource Type
- Journal article
- Publication Details
- Nutritional neuroscience, Vol.25(7), pp.1558-1564
- DOI
- 10.1080/1028415X.2021.1879541
- PMID
- 33939947
- NLM abbreviation
- Nutr Neurosci
- ISSN
- 1028-415X
- eISSN
- 1476-8305
- Publisher
- Taylor & Francis
- Language
- English
- Electronic publication date
- 05/03/2021
- Date published
- 2022
- Academic Unit
- Psychiatry; Stead Family Department of Pediatrics; Epidemiology; Iowa Neuroscience Institute; Developmental and Behavioral Pediatrics; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984071963002771
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