Journal article
Association between sleep structure and amnesic mild cognitive impairment in patients with insomnia disorder: a case-control study
Journal of clinical sleep medicine, Vol.17(1), pp.37-43
01/01/2021
DOI: 10.5664/jcsm.8804
PMCID: PMC7849649
PMID: 32946373
Abstract
Study Objectives: To examine the association between sleep structure and amnesic mild cognitive impairment (aMCI) in patients with insomnia disorder.
Methods: A total of 256 patients with insomnia disorder were diagnosed by neurologists, 45 of whom were diagnosed with aMCI according to the Petersen criteria, and 45 participants with intact cognition were chosen as controls matched for age and education. A case-control study was conducted to compare sleep structure between aMCI and control patients with insomnia disorder. We evaluated self-reported sleep problems by the Insomnia Severity Index and objective sleep features by polysomnography. Logistic regression models were used to estimate the associations between sleep parameters and aMCI in patients with insomnia disorder.
Results: There was no significant difference in Insomnia Severity Index scores between the aMCI and control groups. In the logistic regression after adjustment for covariates, people with a longer sleep duration (adjusted odds ratio [aOR] = 0.56, 95% confidence interval [CI]: 0.36-0.89), greater sleep efficiency (aOR = 0.50, 95% CI: 0.32-0.77), and a higher percentage of total sleep time in stage 3 of non-rapid eye movement sleep (N3%) (aOR = 0.02, 95% CI: 0.01-0.15) have a lower relative probability of having aMCI. By contrast, higher N1% (aOR = 2.28, 95% Cl: 1.36-3.82) and wake after sleep onset (aOR = 1.31, 95% Cl: 1.11-1.55) may be risk factors for aMCI in patients with insomnia.
Conclusions: In patients with insomnia disorder, sleep duration, sleep fragmentation, sleep efficiency, N1% and N3% were independently associated with the presence of aMCI. In the clinical setting, if patients with insomnia show much more serious abnormalities in these sleep indices, clinicians should pay attention to their cognitive function. In-depth research would also be worthwhile to elaborate the causality between sleep and cognitive decline.
Details
- Title: Subtitle
- Association between sleep structure and amnesic mild cognitive impairment in patients with insomnia disorder: a case-control study
- Creators
- Li Zhang - Integrated Chinese MedicineTingting Li - Wuhan UniversityYuhua Lei - Wuhan University of Science and TechnologyGuangwen Cheng - Wuhan University of Science and TechnologyBuyun Liu - University of IowaYongFei Yu - Hubei Provincial Hospital of Integrative MedicineHongXiang Yin - Integrated Chinese MedicineLin Song - Integrated Chinese MedicineQiong La - Integrated Chinese MedicineBenchao Li - Wuhan UniversityWei Bao - University of IowaZhenLi Guo - Integrated Chinese MedicineShuang Rong - Wuhan University of Science and Technology
- Resource Type
- Journal article
- Publication Details
- Journal of clinical sleep medicine, Vol.17(1), pp.37-43
- Publisher
- Amer Acad Sleep Medicine
- DOI
- 10.5664/jcsm.8804
- PMID
- 32946373
- PMCID
- PMC7849649
- ISSN
- 1550-9389
- eISSN
- 1550-9397
- Number of pages
- 7
- Grant note
- 81941016 / National Natural Science Foundation of China; National Natural Science Foundation of China (NSFC) WJ2017F004 / Health Commission of Hubei Province
- Language
- English
- Date published
- 01/01/2021
- Academic Unit
- Epidemiology
- Record Identifier
- 9984364541202771
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