Journal article
Association between sociability and diffusion tensor imaging in BALB/cJ mice
NMR in biomedicine, Vol.25(1), pp.104-112
01/2012
DOI: 10.1002/nbm.1722
PMCID: PMC4188421
PMID: 21618305
Abstract
The purpose of this study was to use high‐resolution diffusion tensor imaging (DTI) to investigate the association between DTI metrics and sociability in BALB/c inbred mice. The sociability of prepubescent (30‐day‐old) BALB/cJ mice was operationally defined as the time that the mice spent sniffing a stimulus mouse in a social choice test. High‐resolution ex vivo DTI data on 12 BALB/cJ mouse brains were acquired using a 9.4‐T vertical‐bore magnet. Regression analysis was conducted to investigate the association between DTI metrics and sociability. Significant positive regression (p < 0.001) between social sniffing time and fractional anisotropy was found in 10 regions located in the thalamic nuclei, zona incerta/substantia nigra, visual/orbital/somatosensory cortices and entorhinal cortex. In addition, significant negative regression (p < 0.001) between social sniffing time and mean diffusivity was found in five areas located in the sensory cortex, motor cortex, external capsule and amygdaloid region. In all regions showing significant regression with either the mean diffusivity or fractional anisotropy, the tertiary eigenvalue correlated negatively with the social sniffing time. This study demonstrates the feasibility of using DTI to detect brain regions associated with sociability in a mouse model system. Copyright © 2011 John Wiley & Sons, Ltd.
The purpose of this study was to use high‐resolution diffusion tensor imaging (DTI) to investigate the association between DTI metrics and sociability in BALB/cJ inbred mice. Strong positive regression between the social sniffing time and fractional anisotropy was found in 10 clusters located in the thalamic nuclei, zona incerta/substantia nigra, visual/orbital/somatosensory cortices, and entorhinal cortex. In addition, strong negative regression between the social sniffing time and apparent diffusion coefficient was found in five areas located in the sensory cortex, motor cortex, external capsule and amygdaloid region.
Details
- Title: Subtitle
- Association between sociability and diffusion tensor imaging in BALB/cJ mice
- Creators
- Sungheon Kim - New York University School of MedicineStephen Pickup - University of Pennsylvania School of MedicineAndrew H Fairless - University of Pennsylvania School of Medicine, Translational Research LaboratoryRanjit Ittyerah - University of Pennsylvania School of MedicineHolly C Dow - University of Pennsylvania School of Medicine, Translational Research LaboratoryTed Abel - University of Pennsylvania, 204G Lynch LaboratoriesEdward S Brodkin - University of Pennsylvania School of Medicine, Translational Research LaboratoryHarish Poptani - University of Pennsylvania School of Medicine
- Resource Type
- Journal article
- Publication Details
- NMR in biomedicine, Vol.25(1), pp.104-112
- DOI
- 10.1002/nbm.1722
- PMID
- 21618305
- PMCID
- PMC4188421
- NLM abbreviation
- NMR Biomed
- ISSN
- 0952-3480
- eISSN
- 1099-1492
- Publisher
- John Wiley & Sons, Ltd; Chichester, UK
- Number of pages
- 9
- Grant note
- NIH (R01MH080718) NIH (R21 HD058237) University of Pennsylvania Translational Biomedical Imaging Center Collaborative Pilot Grant Program
- Language
- English
- Date published
- 01/2012
- Academic Unit
- Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
- Record Identifier
- 9984065734602771
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