Association between tumor-associated macrophage infiltration, high grade prostate cancer, and biochemical recurrence after radical prostatectomy

Kiran Gollapudi; Colette Galet; Tristan Grogan; Hong Zhang; Jonathan W Said; Jiaoti Huang; David Elashoff; Stephen J Freedland; Matthew Rettig; William J Aronson

Association between tumor-associated macrophage infiltration, high grade prostate cancer, and biochemical recurrence after radical prostatectomy

Journal article

Open access

Association between tumor-associated macrophage infiltration, high grade prostate cancer, and biochemical recurrence after radical prostatectomy

Kiran Gollapudi, Colette Galet, Tristan Grogan, Hong Zhang, Jonathan W Said, Jiaoti Huang, David Elashoff, Stephen J Freedland, Matthew Rettig and William J Aronson

American journal of cancer research, Vol.3(5), pp.523-529

01/01/2013

PMID: 24224130

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Abstract

Background: Tumor-associated macrophages (TAMs) are a key component of the inflammatory microenvironment. Their role in prostate cancer development and progression remains unclear. We examined whether the amount of TAMs in prostate cancer is: 1) higher than prostatic intraepithelial neoplasia (PIN) and benign tissue 2) associated with poorly differentiated disease, and 3) predictive of biochemical recurrence among surgically treated men. Methods: A tissue microarray (TMA) of prostatectomy specimens from 332 patients was stained for CD68, a TAM marker. A separate TMA was used for validation. Associations between mean TAMs in cancer cores and PSA recurrence were determined by Cox proportional hazards models after adjusting for age, preoperative PSA, race, body mass index, pathologic Gleason sum, seminal vesicle invasion, extracapsular extension, and margin status. Results: Mean TAM number was higher in cancer versus PIN and benign tissue (p<0.0001). Mean TAM number was higher in Gleason grade 4 cores vs. Gleason grade 3 cores (p=0.003). On multivariable analysis, no association was observed between mean TAM number per cancer core and biochemical recurrence in either cohort. Conclusion: Mean TAM number was higher in cancer cores vs. PIN and benign tissue, and higher in high grade prostate cancer supporting the potential role of TAMs in prostate cancer development. However, TAMs were not associated with biochemical recurrence after radical prostatectomy suggesting TAM counts do not provide independent prognostic value among surgically treated men. Further studies are required to elucidate the functional significance of TAMs in the prostate cancer microenvironment.

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Title: Subtitle: Association between tumor-associated macrophage infiltration, high grade prostate cancer, and biochemical recurrence after radical prostatectomy
Creators: Kiran Gollapudi - University of California, Los Angeles
Colette Galet - University of California, Los Angeles
Tristan Grogan - University of California, Los Angeles
Hong Zhang - University of California, Los Angeles
Jonathan W Said - University of California, Los Angeles
Jiaoti Huang - University of California, Los Angeles
David Elashoff - University of California, Los Angeles
Stephen J Freedland - Duke Medical Center
Matthew Rettig - VA Greater Los Angeles Healthcare System
William J Aronson - University of California, Los Angeles
Resource Type: Journal article
Publication Details: American journal of cancer research, Vol.3(5), pp.523-529
PMID: 24224130
NLM abbreviation: Am J Cancer Res
ISSN: 2156-6976
eISSN: 2156-6976
Publisher: e-Century Publishing Corporation
Number of pages: 7
Language: English
Date published: 01/01/2013
Academic Unit: Injury Prevention Research Center; University of Iowa Health Care
Record Identifier: 9985140871002771

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