Journal article
Association between urinary tin concentration and diabetes in nationally representative sample of US adults
Journal of diabetes, Vol.10(12), pp.977-983
12/2018
DOI: 10.1111/1753-0407.12798
PMCID: PMC6218306
PMID: 29877038
Abstract
Animal studies indicate that chronic exposure to certain tin compounds induces pancreatic islet cell apoptosis and glucose intolerance. However, little is known about the health effects of environmental tin exposure in humans. Therefore, we evaluated the association of tin exposure with diabetes in a nationally representative sample of US adults.
We used data from a nationally representative population (n = 3371) in the National Health and Nutrition Examination Survey 2011-14. Diabetes (n = 605) was defined as self-reported physician's diagnosis, HbA1c ≥6.5%, fasting plasma glucose ≥126 mg/dL, or 2-h plasma glucose ≥200 mg/dL. Tin concentrations in urine samples were determined by inductively coupled plasma mass spectrometry. Logistic regression with sample weights was used to estimate the odds ratios (ORs) of diabetes and 95% confidence intervals (CIs).
Urinary tin concentrations were higher in individuals with diabetes (weighted median 0.58 μg/L) than those without diabetes (0.39 μg/L). After adjustment for urinary creatinine and other diabetes risk factors, the OR of diabetes comparing the highest with lowest quartile of urinary tin concentrations was 1.6 (95% CI 1.0-2.6; P
= 0.02).
Environmental tin exposure was positively and significantly associated with diabetes in US adults.
Details
- Title: Subtitle
- Association between urinary tin concentration and diabetes in nationally representative sample of US adults
- Creators
- Buyun Liu - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, Iowa, USAYangbo Sun - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, Iowa, USAHans-Joachim Lehmler - Environmental Health Sciences Research Center, University of Iowa, Iowa City, Iowa, USAWei Bao - Center for Global and Regional Environmental Research, University of Iowa, Iowa City, Iowa, USA
- Resource Type
- Journal article
- Publication Details
- Journal of diabetes, Vol.10(12), pp.977-983
- DOI
- 10.1111/1753-0407.12798
- PMID
- 29877038
- PMCID
- PMC6218306
- NLM abbreviation
- J Diabetes
- ISSN
- 1753-0407
- eISSN
- 1753-0407
- Publisher
- Australia
- Grant note
- University of Iowa Environmental Health Sciences Research Center P30 ES005605 / NIEHS NIH HHS R21 HD091458 / NICHD NIH HHS National Institutes of Health NIEHS/NIH P30 ES005605 / National Institutes of Health through the University of Iowa Environmental Health Sciences Research Center
- Language
- English
- Date published
- 12/2018
- Academic Unit
- Occupational and Environmental Health; Epidemiology; Iowa Neuroscience Institute; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9983995182302771
Metrics
29 Record Views