Journal article
Association of 5-HT3B Receptor Gene Polymorphisms with the Efficacy of Ondansetron for Postoperative Nausea and Vomiting
Yonsei medical journal, Vol.56(5), pp.1415-1420
09/01/2015
DOI: 10.3349/ymj.2015.56.5.1415
PMCID: PMC4541676
PMID: 26256989
Abstract
Purpose: Postoperative nausea and vomiting (PONV) is a common problem after general anesthesia. Although 5-hydroxytyptamine type 3 (5-HT3) receptor antagonists have significantly reduced PONV, over 35% of patients treated with ondansetron can experience PONV. In this study, we investigated whether the Y129S and -100_-102AAG deletion polymorphisms of the 5-HT3B receptor gene affect the efficacy of ondanseton in preventing PONV.
Materials and Methods: Two hundred and forty-five adult patients who underwent laparoscopic cholecystectomy were enrolled. Ondansetron 0.1 mg/kg was intravenously administered 30 minutes before the end of surgery. Genomic DNA was prepared from blood samples using a nucleic acid isolation device. Both the Y129S variant and the -100_-102AAG deletion variant were screened for using a single base primer extension assay and a DNA direct sequencing method, respectively. The relationship between genetic polymorphisms and clinical outcomes of ondansetron treatment was investigated.
Results: Among the 5-HT3B AAG deletion genotypes, the incidence of PONV was higher in patients with the homomutant than with other genotypes during the first 2 hours after surgery (p=0.02). There were no significant differences in the incidence of PONV among genotypes at 2-24 hours after surgery. In the Y129S variants of the 5-HT3B receptor gene, there were no significant differences in the incidence of PONV among genotypes during the first 2 hours and at 2-24 hours after surgery.
Conclusion: The response to ondansetron for PONV was significantly influenced by the -100_-102AAG deletion polymorphisms of the 5-HT3B gene. Thus, the -100_-102AAG deletion variants may be a pharmacogenetic predictor for responsiveness to ondansetron for PONV.
Details
- Title: Subtitle
- Association of 5-HT3B Receptor Gene Polymorphisms with the Efficacy of Ondansetron for Postoperative Nausea and Vomiting
- Creators
- Min-Soo Kim - Yonsei UniversityJeong-Rim Lee - Yonsei UniversityEun-Mi Choi - Hallym UniversityEun Ho Kim - Yonsei UniversitySeung Ho Choi - Yonsei University
- Resource Type
- Journal article
- Publication Details
- Yonsei medical journal, Vol.56(5), pp.1415-1420
- DOI
- 10.3349/ymj.2015.56.5.1415
- PMID
- 26256989
- PMCID
- PMC4541676
- NLM abbreviation
- Yonsei Med J
- ISSN
- 0513-5796
- eISSN
- 1976-2437
- Publisher
- Yonsei Univ Coll Medicine
- Number of pages
- 6
- Grant note
- 2010-0004868 / Basic Science Research Program through National Research Foundation of Korea (NRF) - Ministry of Education, Science, and Technology
- Language
- English
- Date published
- 09/01/2015
- Academic Unit
- Anesthesia
- Record Identifier
- 9984806502402771
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