Journal article
Association of ABO Blood Group, Age, Body Mass Index and Symptomatic COVID-19 Infection with Signal Levels of Antibodies to COVID-19
Gynecology & Reproductive Health, Vol.6(1), pp.1-5
02/27/2022
DOI: 10.33425/2639-9342.1174
Abstract
Objective: To determine if ABO blood group, age, body mass index (BMI), or symptomatic COVID-19 infection are associated with COVID-19 antibody response in unvaccinated COVID-19 antibody positive pregnant women at time of delivery. Methods: At the time of delivery, 2,499 consecutive pregnant women were tested for ABO blood group and antibodies to both the spike protein and nucleocapsid protein of the COVID-19 virus. The DiaSorin assay was used for antibody to spike protein analysis and the Roche assay for antibody to nucleocapsid protein. Gamma regression models with a log link were used to compare antibody signals, with blood group, age, and BMI as the predictors. Results: 260 (10.4%) of 2,499 women who had not been vaccinated for COVID-19, were positive for both spike and nucleocapsid protein antibodies to COVID-19. The mean signal for COVID-19 nucleocapsid antibody was significantly lower for blood group AB (p=0.028) compared with blood group O. A relationship between blood group and presence of symptomatic COVID-19 was detected (p = 0.028), with asymptomatic individuals having blood group B at a higher rate than the symptomatic individuals do. No other significant pairwise differences between blood groups were detected. There was no significant difference in signal level of antibodies to COVID-19 spike protein between any of the blood groups. Mean signals for antibodies to spike and nucleocapsid proteins were significantly higher in older women (p=0.001 for spike protein antibody and p=0.002 for nucleocapsid antibody). Significantly higher signal levels of antibody to spike and nucleocapsid proteins were found in women with class 2/3 obesity (p=0.022 and p=0.003, respectively). Conclusions: Pregnant women of AB blood group had lower antibody signal to nucleocapsid protein compared to the O blood group, and women of older age and greater BMI had higher antibody signal to COVID-19 spike and nucleocapsid proteins. There was a significant association between women with blood group B and asymptomatic infections.
Details
- Title: Subtitle
- Association of ABO Blood Group, Age, Body Mass Index and Symptomatic COVID-19 Infection with Signal Levels of Antibodies to COVID-19
- Creators
- Timothy MaxwellLinder WendtClaire CastanedaKatherine MarsdenAnna E. MerrillSamantha SwartzHaley SteffenAva JohnsonPatrick Ten EyckKimberly KenneMary RysavyJ. Brooks Jackson
- Resource Type
- Journal article
- Publication Details
- Gynecology & Reproductive Health, Vol.6(1), pp.1-5
- DOI
- 10.33425/2639-9342.1174
- ISSN
- 2639-9342
- eISSN
- 2639-9342
- Language
- English
- Date published
- 02/27/2022
- Academic Unit
- Pathology; Biostatistics; Obstetrics and Gynecology; Injury Prevention Research Center; VPMA - Administration
- Record Identifier
- 9984339545802771
Metrics
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