Journal article
Association of Age With Timing and Amplitude of Reflected Pressure Waves During Exercise in Men
American journal of hypertension, Vol.24(4), pp.415-420
04/2011
DOI: 10.1038/ajh.2010.261
PMID: 21233799
Abstract
Background
Increased elastic conduit artery stiffness with aging is associated with early wave reflection and increased wasted left ventricular pressure energy (LVEW). The effects of aging on central hemodynamics during exercise have not been well characterized. This study sought to investigate changes in central hemodynamics during cycle exercise in young, middle-aged, and older men.
Methods
Central blood pressure and wave reflection characteristics were measured noninvasively using radial artery applanation tonometry at rest and during cycling exercise (45, 55, and 65% of predicted maximum heart rate (HRmax)) in 14 young (24 ± 1 years), 16 middleaged (49 ± 2 years) and 13 older (73 ± 2 years) men.
Results
Repeated measures analysis of variance revealed significant group-by-time interactions for heart rate, central diastolic blood pressure (DBP), central pulse pressure (PP), PP amplification (PPA ), central aortic pressure augmentation (AP), aortic augmentation index (AIX), and LVEW. Magnitude of change from baseline was significantly different in the older group compared to young and middle-aged groups in response to exercise at 65% of predicted HRmax for AP (+3 ± 1 mm Hg vs. −7 ± 1, P < 0.001 and −3 ± 1 mm Hg, P < 0.001) and LVEW (+724 ± 215 dynes s/cm2 · min vs. −494 ± 199, P < 0.001 and −315 ± 192, P < 0.001).
Conclusions
This study suggests that changes in the timing and amplitude of reflected pressure waves during exercise alter the hemodynamic response to exercise with aging. In response to exercise, AP and LVEW increased in older subjects while young and middle-aged subjects exhibited a decline in AP and no change in LVEW.
American Journal of Hypertension advance online publication 13 January 2011; doi:10.1038/ajh.2010.261
Details
- Title: Subtitle
- Association of Age With Timing and Amplitude of Reflected Pressure Waves During Exercise in Men
- Creators
- Jeffrey S Martin - Department of Applied Physiology and Kinesiology, Center for Exercise Science, College of Health and Human Performance, University of FloridaDarren P Casey - Department of Anesthesiology, Mayo ClinicAlvaro N Gurovich - Department of Applied Physiology and Kinesiology, Center for Exercise Science, College of Health and Human Performance, University of FloridaDarren T Beck - Department of Applied Physiology and Kinesiology, Center for Exercise Science, College of Health and Human Performance, University of FloridaRandy W Braith - Department of Applied Physiology and Kinesiology, Center for Exercise Science, College of Health and Human Performance, University of Florida
- Resource Type
- Journal article
- Publication Details
- American journal of hypertension, Vol.24(4), pp.415-420
- Publisher
- Oxford University Press
- DOI
- 10.1038/ajh.2010.261
- PMID
- 21233799
- ISSN
- 0895-7061
- eISSN
- 1879-1905
- Language
- English
- Date published
- 04/2011
- Academic Unit
- Physical Therapy and Rehabilitation Science; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984047691702771
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