Association of Bisphenol A and Its Substitutes, Bisphenol F and Bisphenol S, with Obesity in United States Children and Adolescents

Buyun Liu; Hans Joachim Lehmler; Yangbo Sun; Guifeng Xu; Qi Sun; Linda G Snetselaar; Robert B Wallace; Wei Bao

doi:10.4093/dmj.2018.0045

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Association of Bisphenol A and Its Substitutes, Bisphenol F and Bisphenol S, with Obesity in United States Children and Adolescents

Journal article

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Association of Bisphenol A and Its Substitutes, Bisphenol F and Bisphenol S, with Obesity in United States Children and Adolescents

Buyun Liu, Hans Joachim Lehmler, Yangbo Sun, Guifeng Xu, Qi Sun, Linda G Snetselaar, Robert B Wallace and Wei Bao

Diabetes & metabolism journal, Vol.43(1), pp.59-75

02/2019

DOI: 10.4093/dmj.2018.0045

PMCID: PMC6387872

PMID: 30793552

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Abstract

Bisphenol F (BPF) and bisphenol S (BPS) are increasingly used as substitutes for bisphenol A (BPA), an environmental obesogen. However, health effects of BPF and BPS remain unclear. In this study, we evaluated the associations of BPA, BPF, and BPS with obesity in children and adolescents. We used data from the U.S. National Health and Nutrition Examination Survey 2013 to 2014, a nationally representative study. We included 745 participants aged 6 to 17 years old. General obesity was defined based on the 2000 Centers for Disease Control and Prevention body mass index-for-age growth charts for the United States. Abdominal obesity was defined as waist-to-height ratio ≥0.5. After adjustment for demographic, socioeconomic and lifestyle factors, and urinary creatinine levels, the odds ratio of general obesity comparing the highest with lowest quartile of urinary bisphenol levels was 1.74 (95% confidence interval [CI], 0.92 to 3.31) for BPA, 1.54 (95% CI, 1.02 to 2.32) for BPF, and 1.36 (95% CI, 0.53 to 3.51) for BPS. Moreover, the associations were stronger in boys than in girls for BPA and BPF. Similar results were observed for abdominal obesity. This study for the first time showed that exposure to BPF, a commonly used substitute for BPA, was positively associated with higher risk of obesity in children and adolescents. The association of BPA and BPF with general and abdominal obesity was primarily observed in boys, suggesting a possible sex difference. Further investigations on the underlying mechanisms are needed.

Body Mass Index

United States - epidemiology

Life Style

Obesity - chemically induced

Sulfones - urine

Humans

Obesity, Abdominal - diagnosis

Sulfones - adverse effects

Male

Sex Characteristics

Creatinine - urine

Socioeconomic Factors

Waist-Height Ratio

Phenols - urine

Benzhydryl Compounds - adverse effects

Benzhydryl Compounds - urine

Phenols - adverse effects

Obesity, Abdominal - epidemiology

Obesity - epidemiology

Adolescent

Nutrition Surveys - methods

Female

Estrogens, Non-Steroidal - adverse effects

Child

Details

Title: Subtitle: Association of Bisphenol A and Its Substitutes, Bisphenol F and Bisphenol S, with Obesity in United States Children and Adolescents
Creators: Buyun Liu - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA, USA
Hans Joachim Lehmler - Department of Occupational and Environmental Health, College of Public Health, University of Iowa, Iowa City, IA, USA
Yangbo Sun - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA, USA
Guifeng Xu - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA, USA
Qi Sun - Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA
Linda G Snetselaar - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA, USA
Robert B Wallace - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA, USA
Wei Bao - Center for Global and Regional Environmental Research, University of Iowa, Iowa City, IA, USA. wei-bao@uiowa.edu
Resource Type: Journal article
Publication Details: Diabetes & metabolism journal, Vol.43(1), pp.59-75
DOI: 10.4093/dmj.2018.0045
PMID: 30793552
PMCID: PMC6387872
NLM abbreviation: Diabetes Metab J
ISSN: 2233-6079
eISSN: 2233-6087
Publisher: Korea (South)
Grant note: P30 ES005605 / NIEHS NIH HHS
Language: English
Date published: 02/2019
Academic Unit: Occupational and Environmental Health; Stead Family Department of Pediatrics; Epidemiology; Iowa Neuroscience Institute; Fraternal Order of Eagles Diabetes Research Center; Injury Prevention Research Center; Internal Medicine
Record Identifier: 9983995170902771

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