Journal article
Association of CHRM2 with IQ: Converging Evidence for a Gene Influencing Intelligence
Behavior genetics, Vol.37(2), pp.265-272
03/2007
DOI: 10.1007/s10519-006-9131-2
PMID: 17160701
Abstract
The cholinergic neurotransmitter system is thought to be involved in many aspects of memory, attention, and higher cognition. In the Collaborative Study on the Genetics of Alcoholism (COGA) sample, we have previously reported linkage and association to the cholinergic muscarinic 2 receptor gene (CHRM2) on chromosome 7 with evoked EEG oscillations (Jones et al. 2004), providing evidence that this gene may be involved in human brain dynamics and cognition. In addition, a small number of genetic markers were genotyped in CHRM2 in the Minnesota Twin and Family Study (Comings et al. 2003) and a Dutch family study (Gosso et al. 2006, in press) and both research groups found evidence that this gene may be involved in intelligence. In the COGA sample, we have extensively genotyped SNPs within and flanking the CHRM2 gene. We find evidence of association with multiple SNPs across CHRM2 and Performance IQ, as measured by the Wechsler Adult Intelligence Scale-Revised (WAIS-R). These results remain significant after taking into account alcohol dependence and depression diagnoses in the sample.
Details
- Title: Subtitle
- Association of CHRM2 with IQ: Converging Evidence for a Gene Influencing Intelligence
- Creators
- Danielle Dick - Department of Psychiatry Washington University in St. Louis 660 South Euclid Ave. Box 8134 St. Louis MO 63130 USAFazil Aliev - Ankara University Ankara TurkeyJohn Kramer - University of Iowa Iowa City IA USAJen Wang - Department of Psychiatry Washington University in St. Louis 660 South Euclid Ave. Box 8134 St. Louis MO 63130 USAAnthony Hinrichs - Department of Psychiatry Washington University in St. Louis 660 South Euclid Ave. Box 8134 St. Louis MO 63130 USASarah Bertelsen - Department of Psychiatry Washington University in St. Louis 660 South Euclid Ave. Box 8134 St. Louis MO 63130 USASam Kuperman - University of Iowa Iowa City IA USAMarc Schuckit - University of California at San Diego San Diego CA USAJohn Nurnberger Jr - Indiana University Indianapolis IN USAHoward Edenberg - Indiana University Indianapolis IN USABernice Porjesz - SUNY Health Science Center at Brooklyn Brooklyn NY USAHenri Begleiter - SUNY Health Science Center at Brooklyn Brooklyn NY USAVictor Hesselbrock - University of Connecticut School of Medicine Farmington CT USAAlison Goate - Department of Psychiatry Washington University in St. Louis 660 South Euclid Ave. Box 8134 St. Louis MO 63130 USALaura Bierut - Department of Psychiatry Washington University in St. Louis 660 South Euclid Ave. Box 8134 St. Louis MO 63130 USA
- Resource Type
- Journal article
- Publication Details
- Behavior genetics, Vol.37(2), pp.265-272
- Publisher
- Kluwer Academic Publishers-Plenum Publishers; New York
- DOI
- 10.1007/s10519-006-9131-2
- PMID
- 17160701
- ISSN
- 0001-8244
- eISSN
- 1573-3297
- Language
- English
- Date published
- 03/2007
- Academic Unit
- Psychiatry; Stead Family Department of Pediatrics
- Record Identifier
- 9984003461702771
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