Journal article
Association of Cardiotoxicity With Doxorubicin and Trastuzumab: A Double-Edged Sword in Chemotherapy
Curēus (Palo Alto, CA), Vol.13(9), pp.e18194-e18194
09/22/2021
DOI: 10.7759/cureus.18194
PMCID: PMC8459919
PMID: 34589374
Abstract
Anticancer drugs play an important role in reducing mortality rates and increasing life expectancy in cancer patients. Treatments include monotherapy and/or a combination of radiation therapy, chemotherapy, hormone therapy, or immunotherapy. Despite great advances in drug development, some of these treatments have been shown to induce cardiotoxicity directly affecting heart function and structure, as well as accelerating the development of cardiovascular disease. Such side effects restrict treatment options and can negatively affect disease management. Consequently, when managing cancer patients, it is vital to understand the mechanisms causing cardiotoxicity to better monitor heart function, develop preventative measures against cardiotoxicity, and treat heart failure when it occurs in this patient population. This review discusses the role and mechanism of major chemotherapy agents with principal cardiovascular complications in cancer patients.
Details
- Title: Subtitle
- Association of Cardiotoxicity With Doxorubicin and Trastuzumab: A Double-Edged Sword in Chemotherapy
- Creators
- Mohanad Gabani - Harlem Hospital CenterDiana Castañeda - California State University Los AngelesQuynh My Nguyen - University of MontanaSoo-Kyoung Choi - Internal Medicine, Harlem Hospital Center, New York, USA Basic Sciences, California State University, Los Angeles, USA Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, San Diego, USA Physiology, Yonsei University, Seoul, KOR Department of Emergency and Critical Care, Shanghai General Hospital, Shanghai, CHN Biological Sciences, Northeastern Illinois University, Chicago, USA School of Pharmacy, West Coast University, Los Angeles, USA Instituto de Química, Pontificia Universidad Católica de Valparaíso, Valparaiso, CHL College of Medicine, University of Iowa, Iowa City, USA Physiology, The University of Tennessee Health Science Center, Memphis, USACheng Chen - Shanghai First People's HospitalAyesha Mapara - Northeastern Illinois UniversityAdam Kassan - West Coast UniversityAlexis A Gonzalez - University of ValparaísoTahsin Khataei - University of IowaKarima Ait-Aissa - University of IowaModar Kassan - University of Tennessee Health Science Center
- Resource Type
- Journal article
- Publication Details
- Curēus (Palo Alto, CA), Vol.13(9), pp.e18194-e18194
- Publisher
- Cureus
- DOI
- 10.7759/cureus.18194
- PMID
- 34589374
- PMCID
- PMC8459919
- ISSN
- 2168-8184
- eISSN
- 2168-8184
- Language
- English
- Date published
- 09/22/2021
- Academic Unit
- Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984361731102771
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