Journal article
Association of Country Income Level With the Characteristics and Outcomes of Critically Ill Patients Hospitalized With Acute Kidney Injury and COVID-19
Kidney international reports, Vol.8(8), pp.1514-1530
08/2023
DOI: 10.1016/j.ekir.2023.05.015
PMCID: PMC10219675
PMID: 37360820
Abstract
Introduction
Acute kidney injury (AKI) has been identified as one of the most common and significant problems in hospitalized patients with COVID-19. However, studies examining the relationship between COVID-19 and AKI in low- and low-middle income countries (LLMIC) are lacking. Given that AKI is known to carry a higher mortality rate in these countries, it is important to understand differences in this population.
Methods
This prospective, observational study examines the AKI incidence and characteristics of 32,210 patients with COVID-19 from 49 countries across all income levels who were admitted to an intensive care unit during their hospital stay.
Results
Among patients with COVID-19 admitted to the intensive care unit, AKI incidence was highest in patients in LLMIC, followed by patients in upper-middle income countries (UMIC) and high-income countries (HIC) (53%, 38%, and 30%, respectively), whereas dialysis rates were lowest among patients with AKI from LLMIC and highest among those from HIC (27% vs. 45%). Patients with AKI in LLMIC had the largest proportion of community-acquired AKI (CA-AKI) and highest rate of in-hospital death (79% vs. 54% in HIC and 66% in UMIC). The association between AKI, being from LLMIC and in-hospital death persisted even after adjusting for disease severity.
Conclusions
AKI is a particularly devastating complication of COVID-19 among patients from poorer nations where the gaps in accessibility and quality of healthcare delivery have a major impact on patient outcomes.
Details
- Title: Subtitle
- Association of Country Income Level With the Characteristics and Outcomes of Critically Ill Patients Hospitalized With Acute Kidney Injury and COVID-19
- Creators
- Lovkesh AroraMarina Wainstein - The University of QueenslandNicholas SpyrisonDanyang DaiMoji GhadimiJonathan Chávez-IñiguezLilia Rizo-TopeteBarbara Wanjiru CitarellaLaura MersonJason PoleRolando Claure-del GranadoDavid JohnsonSally ShrapnelHeryl Ann AbdukahilNurul Najmee AbdulkadirRyuzo AbeLaurent AbelAmal AbrousLara AbsilAndrew AckerShingo AdachiDiana AdriãoSaleh Al AgeelShakeel AhmedKate AinscoughEka AirlanggaTharwat AisaAli Ait HssainYounes Ait TamlihatTakako AkimotoErnita AkmalChika AkwaniEman Al QasimRazi AlalqamAngela AlbertiTala Al-DabbousSenthilkumar AlegesanMarta AlessiBeatrice AlexKévin AlexandreAbdulrahman Al-FaresHuda AlfoudriImran AliKazali Enagnon AlidjnouJeffrey AliudinQabas AlkhafajeeClotilde AllavenaNathalie AllouJoão AlvesRita AlvesJoana Alves CabritaMaria AmaralNur AmiraPhoebe AmpawRoberto AndiniClaire AndréjakAndrea AnghebenFrançois AngoulvantSéverine AnsartSivanesen AnthonidassMassimo AntonelliCarlos Alexandre Antunes de BritoArdiyan ApriyanaYaseen ArabiIrene AragaoFrancisco ArancibiaCarolline AraujoAntonio ArcadipanePatrick ArchambaultLukas ArenzJean-Benoît ArletChristel Arnold-DayRakesh AroraElise Artaud-MacariDiptesh AryalAngel AsensioMuhammad AshrafJean Baptiste AssieAmirul AsyrafMinahel AtifAnika AtiqueJohann AuchabieHugues AumaitreAdrien AuvetLaurène AzemarCecile AzoulayBenjamin BachDelphine BacheletClaudine BadrJ. Kenneth BaillieJ Kevin BairdErica BakAgamemnon BakakosNazreen Abu BakarAndriy BalMohanaprasanth BalakrishnanValeria BalanFirouzé Bani-SadrRenata BarbalhoISARIC Characterization Group
- Resource Type
- Journal article
- Publication Details
- Kidney international reports, Vol.8(8), pp.1514-1530
- DOI
- 10.1016/j.ekir.2023.05.015
- PMID
- 37360820
- PMCID
- PMC10219675
- NLM abbreviation
- Kidney Int Rep
- ISSN
- 2468-0249
- eISSN
- 2468-0249
- Publisher
- Elsevier
- Language
- English
- Date published
- 08/2023
- Academic Unit
- Anesthesia
- Record Identifier
- 9984539658902771
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