Journal article
Association of Cystatin C with Measures of Obesity and Its Impact on Cardiovascular Events Among Healthy US Adults
Metabolic syndrome and related disorders, Vol.12(9), pp.472-476
11/01/2014
DOI: 10.1089/met.2014.0018
PMID: 25118891
Abstract
Background:
This study sought to explore the relationship between cystatin C (CysC) and anthropometric measures of obesity and the influence of this association on mortality [cardiovascular disease (CVD), coronary heart disease, and all-cause] in a nationally representative population free of CVD, diabetes mellitus, and macroalbuminuria (MA).
Methods:
The study cohort included 4577 adult participants of the Third National Health and Nutrition Examination Survey (NHANES). Spearman correlation analysis was performed to ascertain the association between various anthropometric measures and CysC. Formal statistical analyses of the interaction term between anthropometric measures and CysC for outcomes were performed followed by stratified multivariate Cox proportional hazard analyses.
Results:
A moderate degree of association was seen between CysC and measures of visceral adiposity as represented by waist-to-height ratio (WHR) and waist circumference (WC) and only a weak association between CysC and body mass index (BMI). CysC was predictive of all study outcomes in individuals with normal anthropometric measurements only.
Conclusions:
CysC correlated better with measures of visceral adiposity (WC and WHR) compared to BMI and appears to be a better predictor of adverse cardiovascular outcomes among those with anthropometric measures not suggestive of obesity compared to those with abnormal measures of anthropometry.
Details
- Title: Subtitle
- Association of Cystatin C with Measures of Obesity and Its Impact on Cardiovascular Events Among Healthy US Adults
- Creators
- Sidakpal S Panaich - 1Department of Cardiology, Wayne State University/Detroit Medical Center, Detroit, MichiganVikas Veeranna - 1Department of Cardiology, Wayne State University/Detroit Medical Center, Detroit, MichiganChirag Bavishi - 2Mount Sinai St. Luke's–Roosevelt Hospital, New York, New YorkSandip K Zalawadiya - 1Department of Cardiology, Wayne State University/Detroit Medical Center, Detroit, MichiganAnupama Kottam - 1Department of Cardiology, Wayne State University/Detroit Medical Center, Detroit, MichiganLuis Afonso - 1Department of Cardiology, Wayne State University/Detroit Medical Center, Detroit, Michigan
- Resource Type
- Journal article
- Publication Details
- Metabolic syndrome and related disorders, Vol.12(9), pp.472-476
- Publisher
- Mary Ann Liebert, Inc
- DOI
- 10.1089/met.2014.0018
- PMID
- 25118891
- ISSN
- 1540-4196
- eISSN
- 1557-8518
- Language
- English
- Date published
- 11/01/2014
- Academic Unit
- Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984094530302771
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