Association of Dynamics in Lean and Fat Mass Measures with Mortality in Frail Older Women

O Zaslavsky; E Rillamas-Sun; W Li; S Going; M Datta; L Snetselaar; S Zelber-Sagi

doi:10.1007/s12603-016-0730-1

Back

Association of Dynamics in Lean and Fat Mass Measures with Mortality in Frail Older Women

Journal article

Peer reviewed

Association of Dynamics in Lean and Fat Mass Measures with Mortality in Frail Older Women

O Zaslavsky, E Rillamas-Sun, W Li, S Going, M Datta, L Snetselaar and S Zelber-Sagi

The Journal of nutrition, health & aging, Vol.21(1), pp.112-119

2017

DOI: 10.1007/s12603-016-0730-1

PMID: 27999857

Files and links (1)

url

https://www.ncbi.nlm.nih.gov/pmc/articles/12879082View

Open Access

Abstract

The relationship between body composition and mortality in frail older people is unclear. We used dual-x-ray absorptiometry (DXA) data to examine the association between dynamics in whole-body composition and appendicular (4 limbs) and central (trunk) compartments and all-cause mortality in frail older women. Prospective study with up to 19 years of follow up. Community dwelling older (≥65) women. 876 frail older participants of the Women's Health Initiative Observational Study with a single measure of body composition and 581 participants with two measures. Frailty was determined using modified Fried's criteria. All-cause mortality hazard was modeled as a function of static (single-occasion) or dynamic changes (difference between two time points) in body composition using Cox regression. Analyses adjusted for age, ethnicity, income, smoking, cardiovascular disease, diabetes, stroke, number of frailty criteria and whole-body lean mass showed progressively decreased rates of mortality in women with higher appendicular fat mass (FM) (P for trend=0.01), higher trunk FM (P for trend=0.03) and higher whole-body FM (P for trend=0.01). The hazard rate ratio for participants with more than a 5% decline in FM between two time points was 1.91; 1.67 and 1.71 for appendicular, trunk and whole-body compartment respectively as compared to women with relatively stable adiposity (p<0.05 for all). Dynamics of more than 5% in lean mass were not associated with mortality. Low body fat or a pronounced decline in adiposity is associated with increased risks of mortality in frail older women. These results indicate a need to re-evaluate healthy weight in persons with frailty. .

Body Mass Index

Body Weight

Prospective Studies

Follow-Up Studies

Humans

Middle Aged

Proportional Hazards Models

Frail Elderly

Absorptiometry, Photon

Adiposity

Observational Studies as Topic

Female

Aged

Details

Title: Subtitle: Association of Dynamics in Lean and Fat Mass Measures with Mortality in Frail Older Women
Creators: O Zaslavsky - Oleg Zaslavsky, PhD, Biobehavioral Nursing and Health Systems, University of Washington, Seattle, WA, USA, Email: oleg.zaslavsky@fulbrightmail.org, Phone number: 206-849-3301
E Rillamas-Sun
W Li - University of Massachusetts Chan Medical School
S Going
M Datta
L Snetselaar
S Zelber-Sagi
Resource Type: Journal article
Publication Details: The Journal of nutrition, health & aging, Vol.21(1), pp.112-119
DOI: 10.1007/s12603-016-0730-1
PMID: 27999857
NLM abbreviation: J Nutr Health Aging
ISSN: 1279-7707
eISSN: 1760-4788
Publisher: France
Grant note: N01WH32111 / WHI NIH HHS N01WH42129 / WHI NIH HHS N01WH32122 / WHI NIH HHS N01WH32108 / WHI NIH HHS N01WH32118 / NHLBI NIH HHS N01WH42107 / NHLBI NIH HHS N01WH32119 / WHI NIH HHS N01WH32100 / WHI NIH HHS N01WH32115 / WHI NIH HHS N01WH24152 / WHI NIH HHS N01WH32105 / NHLBI NIH HHS N01WH44221 / WHI NIH HHS N01WH22110 / WHI NIH HHS
Language: English
Date published: 2017
Academic Unit: Epidemiology; Internal Medicine
Record Identifier: 9983995059802771

Metrics

29 Record Views

11 Times Cited - Web of Science