Association of ERAP1 , IL23R and PTGER4 Polymorphisms with Radiographic Severity of Ankylosing Spondylitis

Gulsen Ozen; Rabia Deniz; Fatih Eren; Can Erzik; Ali Ugur Unal; Sule Yavuz; Sibel Zehra Aydin; Nevsun Inanc; Haner Direskeneli; Pamir Atagunduz

doi:10.2174/1874312901711010001

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Association of ERAP1 , IL23R and PTGER4 Polymorphisms with Radiographic Severity of Ankylosing Spondylitis

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Association of ERAP1 , IL23R and PTGER4 Polymorphisms with Radiographic Severity of Ankylosing Spondylitis

Gulsen Ozen, Rabia Deniz, Fatih Eren, Can Erzik, Ali Ugur Unal, Sule Yavuz, Sibel Zehra Aydin, Nevsun Inanc, Haner Direskeneli and Pamir Atagunduz

The open rheumatology journal, Vol.11(1), pp.1-9

01/01/2017

DOI: 10.2174/1874312901711010001

PMCID: PMC5366379

PMID: 28400866

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Abstract

Radiographic severity of ankylosing spondylitis (AS) shows such great variance that some patients never develop syndesmophytes throughout the entire disease span, whereas some develop bamboo spine relatively early. To study the association between , and single nucleotide polymorphisms (SNPs) and radiographic severity in AS patients. rs27044 and rs30187 ( ), rs11209032 ( ) and rs10440635 ( ) SNPs were genotyped in 235 AS patients fulfilling the modified New York criteria. Patients were classified as mild- and severe-AS according to modified Stoke AS spinal score (mSASSS). Mild-AS is defined as having mSASSS of "0" following at least 10 years of disease duration. Severe-AS is defined as having mSASSS of >20 (patients with mild vertebral changes ( squaring or erosions) were omitted for clear stratification) regardless of disease duration. The genotype distributions and allele frequencies of rs27044 and rs30187, rs11209032 and rs10440635 SNPs were similar in mild- (n=171, mSASSS=0, 55.6% HLA-B27 positive) and severe-AS patients (n=64, mSASSS=48.5±17.8, 73.4% HLA-B27 positive). After adjustment for clinical differences between groups (gender, disease duration, HLA-B27 and smoking status) by logistic regression analysis, none of the alleles in the investigated SNPs were found to be associated with radiographic severity of AS. In radiographically well-categorized AS patients, rs27044 and rs30187, rs11209032 and rs10440635 SNPs are not found to be associated with radiographic severity of AS.

PTGER4

IL23R

radiographic severity

Ankylosing spondylitis

ERAP1

Details

Title: Subtitle: Association of ERAP1 , IL23R and PTGER4 Polymorphisms with Radiographic Severity of Ankylosing Spondylitis
Creators: Gulsen Ozen - Marmara University
Rabia Deniz - Marmara University
Fatih Eren - Marmara University
Can Erzik - Marmara University
Ali Ugur Unal - Marmara University
Sule Yavuz - Istanbul Bilim University
Sibel Zehra Aydin - Department of Rheumatology, School of Medicine, Ottawa University, Ottawa, Ontario, Canada
Nevsun Inanc - Marmara University
Haner Direskeneli - Marmara University
Pamir Atagunduz - Marmara University
Resource Type: Journal article
Publication Details: The open rheumatology journal, Vol.11(1), pp.1-9
DOI: 10.2174/1874312901711010001
PMID: 28400866
PMCID: PMC5366379
NLM abbreviation: Open Rheumatol J
ISSN: 1874-3129
eISSN: 1874-3129
Language: English
Date published: 01/01/2017
Academic Unit: Internal Medicine
Record Identifier: 9984702775802771

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