Association of Epigenetic Age Acceleration With Incident Mild Cognitive Impairment and Dementia Among Older Women

Aladdin H Shadyab; Linda K McEvoy; Steve Horvath; Eric A Whitsel; Stephen R Rapp; Mark A Espeland; Susan M Resnick; JoAnn E Manson; Jiu-Chiuan Chen; Brian H Chen; Wenjun Li; Kathleen M Hayden; Wei Bao; Cynthia D J Kusters; Andrea Z LaCroix

doi:10.1093/gerona/glab245

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Association of Epigenetic Age Acceleration With Incident Mild Cognitive Impairment and Dementia Among Older Women

Journal article

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Association of Epigenetic Age Acceleration With Incident Mild Cognitive Impairment and Dementia Among Older Women

Aladdin H Shadyab, Linda K McEvoy, Steve Horvath, Eric A Whitsel, Stephen R Rapp, Mark A Espeland, Susan M Resnick, JoAnn E Manson, Jiu-Chiuan Chen, Brian H Chen, …

The journals of gerontology. Series A, Biological sciences and medical sciences, Vol.77(6), pp.1239-1244

06/01/2022

DOI: 10.1093/gerona/glab245

PMCID: PMC9159659

PMID: 34417803

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https://www.ncbi.nlm.nih.gov/pmc/articles/9159659View

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Abstract

Epigenetic age acceleration (AgeAccel), which indicates faster biological aging relative to chronological age, has been associated with lower cognitive function. However, the association of AgeAccel with mild cognitive impairment (MCI) or dementia is not well-understood. We examined associations of 4 AgeAccel measures with incident MCI and dementia. This prospective analysis included 578 older women from the Women's Health Initiative Memory Study selected for a case-cohort study of coronary heart disease (CHD). Women were free of CHD and cognitive impairment at baseline. Associations of AgeAccel measures (intrinsic AgeAccel [IEAA], extrinsic AgeAccel [EEAA], AgeAccelPheno, and AgeAccelGrim) with risks for incident adjudicated diagnoses of MCI and dementia overall and stratified by incident CHD status were evaluated. IEAA was not significantly associated with MCI (HR, 1.23; 95% CI, 0.99-1.53), dementia (HR, 1.10; 95% CI, 0.88-1.38), or cognitive impairment (HR, 1.18; 95% CI, 0.99-1.40). In stratified analysis by incident CHD status, there was a 39% (HR, 1.39; 95% CI, 1.07-1.81) significantly higher risk of MCI for every 5-year increase in IEAA among women who developed CHD during follow-up. Other AgeAccel measures were not significantly associated with MCI or dementia. IEAA was not significantly associated with cognitive impairment overall but was associated with impairment among women who developed CHD. Larger studies designed to examine associations of AgeAccel with cognitive impairment are needed, including exploration of whether associations are stronger in the setting of underlying vascular pathologies.

Acceleration

Aged

Cognitive Dysfunction - complications

Cognitive Dysfunction - epidemiology

Cognitive Dysfunction - genetics

Cohort Studies

Dementia - complications

Dementia - epidemiology

Dementia - genetics

Epigenesis, Genetic

Female

Humans

Prospective Studies

Details

Title: Subtitle: Association of Epigenetic Age Acceleration With Incident Mild Cognitive Impairment and Dementia Among Older Women
Creators: Aladdin H Shadyab - Human Longevity (United States)
Linda K McEvoy - Human Longevity (United States)
Steve Horvath - University of California, Los Angeles
Eric A Whitsel - University of North Carolina at Chapel Hill
Stephen R Rapp - Wake Forest University
Mark A Espeland - Wake Forest University
Susan M Resnick - National Institute on Aging
JoAnn E Manson - Brigham and Women's Hospital
Jiu-Chiuan Chen - University of Southern California
Brian H Chen - Human Longevity (United States)
Wenjun Li - University of Massachusetts Lowell
Kathleen M Hayden - Wake Forest University
Wei Bao - University of Iowa
Cynthia D J Kusters - University of California, Los Angeles
Andrea Z LaCroix - Human Longevity (United States)
Resource Type: Journal article
Publication Details: The journals of gerontology. Series A, Biological sciences and medical sciences, Vol.77(6), pp.1239-1244
DOI: 10.1093/gerona/glab245
PMID: 34417803
PMCID: PMC9159659
NLM abbreviation: J Gerontol A Biol Sci Med Sci
ISSN: 1079-5006
eISSN: 1758-535X
Grant note: U01 AG060908 / NIA NIH HHS NHLBI NIH HHS NIH HHS HHSN-268-2004-6-4221C / Wyeth-Ayerst Pharmaceuticals 60442456 BAA23 / U.S. Department of Health and Human Services HHSN-271-2017-00002C / NIA NIH HHS
Language: English
Date published: 06/01/2022
Academic Unit: Epidemiology
Record Identifier: 9984364538102771

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