Journal article
Association of Fetuin-A With Incident Fractures in Community-Dwelling Older Adults: The Cardiovascular Health Study
Journal of bone and mineral research, Vol.30(8), pp.1394-1402
08/2015
DOI: 10.1002/jbmr.2475
PMID: 25656814
Abstract
Fetuin-A, a serum protein that regulates calcium mineralization, has been associated with bone mineral density (BMD) in several cross-sectional human studies, suggesting a possible beneficial effect on clinically important measures of bone health. Fetuin-A and incidence of subsequent fracture was assessed in 4714 men and women ≥65 years of age. Proportional hazards models were used to estimate risk of incident hip (hospital discharge ICD-9 codes) and composite fracture (hip, pelvis, humerus, or proximal forearm; hospital discharge ICD-9 codes and Medicare claims data). A total of 576 participants had an incident hip fracture (median follow-up 11.2 years) and 768 had an incident composite fracture (median follow-up 6.9 years). In unadjusted analyses, there was no association between fetuin-A (per SD increase) and risk of hip fracture (hazard ratio [HR], 0.96; 95% CI, 0.88 to 1.05) or composite fracture (HR, 0.99; 95% CI, 0.92 to 1.06). Results were not significantly changed after adjustment for potential confounding variables. Analyses modeling fetuin-A in quartiles or within a subset with available BMD measures also showed no statistically significant association with risk of hip or composite fracture. Though fetuin-A was positively associated with areal BMD in partially adjusted models (total hip: β, 0.013 g/cm(2) ; 95% CI, 0.005 to 0.021; femoral neck: β, 0.011 g/cm(2) ; 95% CI, 0.004 to 0.018; and lumbar spine: β, 0.007 g/cm(2) ; 95% CI, 0.001 to 0.028), these associations were no longer significant after further adjustment for BMI and in final multivariate models. In this large sample of community-dwelling older adults, a small positive association between fetuin-A and areal BMD appeared attributable to confounding variables and we found no evidence of an association between fetuin-A and risk of clinical fracture.
Details
- Title: Subtitle
- Association of Fetuin-A With Incident Fractures in Community-Dwelling Older Adults: The Cardiovascular Health Study
- Creators
- Howard A Fink - Division of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USAPetra Bůžková - Department of Biostatistics, University of Washington, Seattle, WA, USAPranav S Garimella - Division of Nephrology, Tufts Medical Center, Boston, MA, USAKenneth J Mukamal - Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, MA, USAJane A Cauley - Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USAJorge R Kizer - Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USAJoshua I Barzilay - Division of Endocrinology, Emory University School of Medicine, Atlanta, GA, USADiana I Jalal - Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Center, Aurora, CO, USAJoachim H Ix - Division of Nephrology-Hypertension, University of California San Diego, San Diego, CA, USA
- Resource Type
- Journal article
- Publication Details
- Journal of bone and mineral research, Vol.30(8), pp.1394-1402
- DOI
- 10.1002/jbmr.2475
- PMID
- 25656814
- ISSN
- 0884-0431
- eISSN
- 1523-4681
- Grant note
- N01HC85080 / NHLBI NIH HHS N01HC55222 / NHLBI NIH HHS N01HC85086 / NHLBI NIH HHS R01AG023629 / NIA NIH HHS N01HC85082 / NHLBI NIH HHS N01HC85081 / NHLBI NIH HHS N01HC85083 / NHLBI NIH HHS N01HC85079 / NHLBI NIH HHS HL094555 / NHLBI NIH HHS 080295 / PHS HHS
- Language
- English
- Date published
- 08/2015
- Academic Unit
- Nephrology; Internal Medicine
- Record Identifier
- 9984094509002771
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