Journal article
Association of GABRA2 with Drug Dependence in the Collaborative Study of the Genetics of Alcoholism Sample
Behavior genetics, Vol.36(5), pp.640-650
09/2006
DOI: 10.1007/s10519-006-9069-4
PMID: 16622805
Abstract
Results from twin studies suggest that overlapping genetic factors influence alcohol dependence and illicit drug dependence. Using data from the Collaborative Study on the Genetics of Alcoholism (COGA), we examined the association between 69 SNPs in the GABAA receptor gene cluster on chromosome 4 and marijuana and illicit drug dependence, individually, and as co-occurring phenotypes with alcohol dependence. Results suggested association between marijuana dependence and illicit drug dependence with SNPs in the GABRA2 gene. Interestingly, the evidence for association previously observed with alcohol dependence came only from individuals with comorbid illicit drug dependence. There was no association with other genes in the GABAA cluster on chromosome 4 with illicit drug dependence.
Details
- Title: Subtitle
- Association of GABRA2 with Drug Dependence in the Collaborative Study of the Genetics of Alcoholism Sample
- Creators
- Arpana Agrawal - Department of Psychiatry Washington University in St. Louis St. Louis MO USAHoward J Edenberg - Indiana University School of Medicine Indianapolis IN USATatiana Foroud - Indiana University School of Medicine Indianapolis IN USALaura J Bierut - Department of Psychiatry Washington University in St. Louis St. Louis MO USAGerald Dunne - Department of Psychiatry Washington University in St. Louis St. Louis MO USAAnthony L Hinrichs - Department of Psychiatry Washington University in St. Louis St. Louis MO USAJohn I Nurnberger - Indiana University School of Medicine Indianapolis IN USARaymond Crowe - University of Iowa Iowa City IA USASamuel Kuperman - University of Iowa Iowa City IA USAMarc A Schuckit - University of California–San Diego San Diego CA USAHenri Begleiter - State University of New York New York NY USABernice Porjesz - State University of New York New York NY USADanielle M Dick - Department of Psychiatry Washington University in St. Louis Box 8134 660 South Euclid Avenue St. Louis MO 63130 USA
- Resource Type
- Journal article
- Publication Details
- Behavior genetics, Vol.36(5), pp.640-650
- Publisher
- Kluwer Academic Publishers-Plenum Publishers; New York
- DOI
- 10.1007/s10519-006-9069-4
- PMID
- 16622805
- ISSN
- 0001-8244
- eISSN
- 1573-3297
- Language
- English
- Date published
- 09/2006
- Academic Unit
- Psychiatry; Stead Family Department of Pediatrics
- Record Identifier
- 9984003926802771
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