Journal article
Association of Ground Glass Opacities with Systemic Inflammation and Progression of Emphysema
American journal of respiratory and critical care medicine, Vol.210(12), pp.1432-1440
12/15/2024
DOI: 10.1164/rccm.202310-1825OC
PMCID: PMC11716031
PMID: 38843116
Abstract
Rational: Ground glass opacities (GGO) in the absence of interstitial lung disease are understudied. Objective: To assess the association of GGO with white blood cells (WBCs) and progression of quantified chest CT emphysema. Methods: We analyzed data of participants in the Subpopulations and Intermediate Outcome Measures In COPD Study (SPIROMICS). Chest radiologists and pulmonologists labeled regions of the lung as GGO and adaptive multiple feature method (AMFM) trained the computer to assign those labels to image voxels and quantify the volume of the lung with GGO (%GGOAMFM). We used multivariable linear regression, zero-inflated negative binomial, and proportional hazards regression models to assess the association of %GGOAMFM with WBC, changes in %emphysema, and clinical outcomes. Measurements and Main Results: Among 2,714 participants, 1,680 had COPD and 1,034 had normal spirometry. Among COPD participants, based on the multivariable analysis, current smoking and chronic productive cough was associated with higher %GGOAMFM. Higher %GGOAMFM was cross-sectionally associated with higher WBCs and neutrophils levels. Higher %GGOAMFM per interquartile range at visit 1 (baseline) was associated with an increase in emphysema at one-year follow visit by 11.7% (Relative increase; 95%CI 7.5-16.1%;P<0.001). We found no association between %GGOAMFM and one-year FEV1 decline but %GGOAMFM was associated with exacerbations and all-cause mortality during a median follow-up time of 1,544 days (Interquartile Interval=1,118-2,059). Among normal spirometry participants, we found similar results except that %GGOAMFM was associated with progression to COPD at one-year follow-up. Conclusions: Our findings suggest that GGOAMFM is associated with increased systemic inflammation and emphysema progression.
Details
- Title: Subtitle
- Association of Ground Glass Opacities with Systemic Inflammation and Progression of Emphysema
- Creators
- Spyridon Fortis - University of IowaJunfeng Guo - University of IowaPrashant Nagpal - University of Wisconsin–MadisonMuhammad F A Chaudhary - University of IowaJohn D Jr Newell - University of Iowa, RadiologySarah E Gerard - University of IowaMeiLan K Han - University of MichiganElla A Kazerooni - University of MichiganFernando J Martinez - Cornell UniversityIgor Z Barjaktarevic - University of California, Los AngelesR Graham Barr - Columbia UniversitySandeep Bodduluri - University of Alabama at BirminghamRobert Paine III - University of UtahHira A Awan - University of IowaJoyce D Schroeder - University of Utah HospitalLisa D Gravens-Mueller - University of North Carolina at Chapel HillVictor E Ortega - Mayo Clinic in ArizonaWayne H Anderson - University of North Carolina at Chapel HillChristopher B Cooper - Harbor–UCLA Medical CenterDavid Couper - University of North Carolina at Chapel HillPrescott G Woodruff - University of California, San FranciscoRussell P Bowler - National Jewish HealthSurya P Bhatt - University of Alabama at BirminghamEric A Hoffman - University of Iowa, RadiologyJoseph M Reinhardt - University of IowaAlejandro P Comellas - University of Iowa
- Resource Type
- Journal article
- Publication Details
- American journal of respiratory and critical care medicine, Vol.210(12), pp.1432-1440
- DOI
- 10.1164/rccm.202310-1825OC
- PMID
- 38843116
- PMCID
- PMC11716031
- NLM abbreviation
- Am J Respir Crit Care Med
- eISSN
- 1535-4970
- Language
- English
- Electronic publication date
- 06/06/2024
- Date published
- 12/15/2024
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Pulmonary, Critical Care, and Occupational Medicine; ICTS; Internal Medicine
- Record Identifier
- 9984641860302771
Metrics
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