Journal article
Association of Household Exposure to Primary Clostridioides difficile Infection With Secondary Infection in Family Members
JAMA network open, Vol.3(6), pp.e208925-e208925
06/01/2020
DOI: 10.1001/jamanetworkopen.2020.8925
PMCID: PMC7320299
PMID: 32589232
Abstract
Clostridioides difficile infection (CDI) is a common hospital-acquired infection. Whether family members are more likely to experience a CDI following CDI in another separate family member remains to be studied.
To determine the incidence of potential family transmission of CDI.
In this case-control study comparing the incidence of CDI among individuals with prior exposure to a family member with CDI to those without prior family exposure, individuals were binned into monthly enrollment strata based on exposure status (eg, family exposure) and confounding factors (eg, age, prior antibiotic use). Data were derived from population-based, longitudinal commercial insurance claims from the Truven Marketscan Commercial Claims and Encounters and Medicare Supplemental databases from 2001 to 2017. Households with at least 2 family members continuously enrolled for at least 1 month were eligible. CDI incidence was computed within each stratum. A regression model was used to compare incidence of CDI while controlling for possible confounding characteristics.
Index CDI cases were identified using inpatient and outpatient diagnosis codes. Exposure risks 60 days prior to infection included CDI diagnosed in another family member, prior hospitalization, and antibiotic use.
The primary outcome was the incidence of CDI in a given monthly enrollment stratum. Separate analyses were considered for CDI diagnosed in outpatient or hospital settings.
A total of 224 818 cases of CDI, representing 194 424 enrollees (55.9% female; mean [SD] age, 52.8 [22.2] years) occurred in families with at least 2 enrollees. Of these, 1074 CDI events (4.8%) occurred following CDI diagnosis in a separate family member. Prior family exposure was significantly associated with increased incidence of CDI, with an incidence rate ratio (IRR) of 12.47 (95% CI, 8.86-16.97); this prior family exposure represented the factor with the second highest IRR behind hospital exposure (IRR, 16.18 [95% CI, 15.31-17.10]). For community-onset CDI cases without prior hospitalization, the IRR for family exposure was 21.74 (95% CI, 15.12-30.01). Age (IRR, 9.90 [95% CI, 8.92-10.98] for ages ≥65 years compared with ages 0-17 years), antibiotic use (IRR, 3.73 [95% CI, 3.41-4.08] for low-risk and 14.26 [95% CI, 13.27-15.31] for high-risk antibiotics compared with no antibiotics), and female sex (IRR, 1.44 [95% CI, 1.36-1.53]) were also positively associated with incidence.
This study found that individuals with family exposure may be at significantly greater risk for acquiring CDI, which highlights the importance of the shared environment in the transmission and acquisition of C difficile.
Details
- Title: Subtitle
- Association of Household Exposure to Primary Clostridioides difficile Infection With Secondary Infection in Family Members
- Creators
- Aaron C Miller - Department of Epidemiology, University of Iowa, Iowa CityAlberto M Segre - Department of Computer Science, University of Iowa, Iowa CitySriram V Pemmaraju - Department of Computer Science, University of Iowa, Iowa CityDaniel K Sewell - Department of Biostatistics, University of Iowa, Iowa CityPhilip M Polgreen - Department of Internal Medicine, University of Iowa, Iowa City
- Resource Type
- Journal article
- Publication Details
- JAMA network open, Vol.3(6), pp.e208925-e208925
- DOI
- 10.1001/jamanetworkopen.2020.8925
- PMID
- 32589232
- PMCID
- PMC7320299
- NLM abbreviation
- JAMA Netw Open
- ISSN
- 2574-3805
- eISSN
- 2574-3805
- Language
- English
- Date published
- 06/01/2020
- Academic Unit
- Infectious Diseases; Epidemiology; Biostatistics; Nursing; Fraternal Order of Eagles Diabetes Research Center; Injury Prevention Research Center; Computer Science; Public Policy Center (Archive); Internal Medicine
- Record Identifier
- 9984214706102771
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