Association of KCNB1 to rheumatoid arthritis via interaction with HLA-DRB1

Xiangjun Xiao; Yufang Zhang; Kai Wang

doi:10.1186/1753-6561-3-s7-s134

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Association of KCNB1 to rheumatoid arthritis via interaction with HLA-DRB1

Journal article

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Association of KCNB1 to rheumatoid arthritis via interaction with HLA-DRB1

Xiangjun Xiao, Yufang Zhang and Kai Wang

BMC proceedings, Vol.3(Suppl 7), pp.S134-S134

12/15/2009

DOI: 10.1186/1753-6561-3-s7-s134

PMCID: PMC2795908

PMID: 20018001

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Abstract

With the rapid development of large-scale high-throughput genotyping technology, genome-wide association studies have become a popular approach to mapping genes underlying common human disorders. Some genes are discovered, but many more have not been. Because these genes were not initially identified, it is reasonable to assume that their main effect is weak. We propose a method to accommodate such a situation. It is applied to the Genetic Analysis Workshop 16 Problem 1 case-control data in which shared-epitope alleles of HLA-DRB1 show very strong association with rheumatoid arthritis. Because some previous functional studies have reported association of gene KCNB1 to rheumatoid arthritis, we evaluate whether the gene KCNB1 contributes to the genetics of rheumatoid arthritis in this data set. Fifteen single-nucleotide polymorphisms from this gene were chosen. The association of KCNB1 gene to rheumatoid arthritis seems to be moderate.

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Details

Title: Subtitle: Association of KCNB1 to rheumatoid arthritis via interaction with HLA-DRB1
Creators: Xiangjun Xiao - Department of Biostatistics, University of Iowa, 200 Hawkins Drive C227 GH, Iowa City, Iowa 52242, USA
Yufang Zhang - Department of Biostatistics, University of Iowa, 200 Hawkins Drive C227 GH, Iowa City, Iowa 52242, USA
Kai Wang - Department of Biostatistics, University of Iowa, 200 Hawkins Drive C227 GH, Iowa City, Iowa 52242, USA
Resource Type: Journal article
Publication Details: BMC proceedings, Vol.3(Suppl 7), pp.S134-S134
DOI: 10.1186/1753-6561-3-s7-s134
PMID: 20018001
PMCID: PMC2795908
NLM abbreviation: BMC Proc
ISSN: 1753-6561
eISSN: 1753-6561
Publisher: BioMed Central
Language: English
Date published: 12/15/2009
Academic Unit: Biostatistics
Record Identifier: 9983997337802771

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