Association of Macular Thickness With Age and Age-Related Macular Degeneration in the Carotenoids in Age-Related Eye Disease Study 2 (CAREDS2), An Ancillary Study of the Women's Health Initiative

Tyler Etheridge; Zhe Liu; Marine Nalbandyan; Spencer Cleland; Barbara A Blodi; Julie A Mares; Steven Bailey; Robert Wallace; Karen Gehrs; Lesley F Tinker; Ronald Gangnon; Amitha Domalpally; CAREDS2 Research Study Group

doi:10.1167/tvst.10.2.39

Back

Association of Macular Thickness With Age and Age-Related Macular Degeneration in the Carotenoids in Age-Related Eye Disease Study 2 (CAREDS2), An Ancillary Study of the Women's Health Initiative

Journal article

Open access

Peer reviewed

Association of Macular Thickness With Age and Age-Related Macular Degeneration in the Carotenoids in Age-Related Eye Disease Study 2 (CAREDS2), An Ancillary Study of the Women's Health Initiative

Tyler Etheridge, Zhe Liu, Marine Nalbandyan, Spencer Cleland, Barbara A Blodi, Julie A Mares, Steven Bailey, Robert Wallace, Karen Gehrs, Lesley F Tinker, …

Translational vision science & technology, Vol.10(2), pp.39-14

02/05/2021

DOI: 10.1167/tvst.10.2.39

PMID: 34003924

Files and links (1)

url

https://doi.org/10.1167/tvst.10.2.39View

Published (Version of record) Open Access

Abstract

To evaluate the relationship of retinal layer thickness with age and age-related macular degeneration (AMD) in the Carotenoids in Age-Related Eye Disease Study 2. Total retinal thickness within the macular area, and individual layer thickness was determined for CAREDS2 participants (n = 906 eyes, 473 women) from the Women's Health Initiative using Heidelberg optical coherence tomography (OCT). Mean measurements within the OCT grid were compared across age tertiles (69-78, 78-83, and 83-101 years) and AMD outcomes. Mean retinal thickness in the central circle, inner ring, and outer ring were 277 ± 34 µm, 326 ± 20 µm, and 282 ± 15 µm, respectively. Thickness did not vary by age in the central circle, but decreased with age in the inner and outer circles (P ≤ 0.004). Specifically, ganglion cell (GCL), inner plexiform, and outer nuclear (ONL) layer thickness decreased with age (P ≤ 0.003). Age-adjusted retinal thickness in all three circles did not vary by AMD outcomes (486 without AMD and 413 with AMD). However, individual layers showed changes with GCL and photoreceptor thinning and retinal pigment epithelial thicknening in eyes with late AMD. After controlling for age and AMD, higher ONL thickness was associated with better visual acuity. In this cohort of older women, a decrease in perifoveal thickness was associated with increasing age, particularly in the inner retinal layers. Variabilty in thickness in AMD eyes was primarily due to outer retinal layers. Among all retinal layers, the ONL plays an important role in preserving visual acuity. The study provides a deeper understanding of age related changes to the retinal layers and their effect on visual loss.

Details

Title: Subtitle: Association of Macular Thickness With Age and Age-Related Macular Degeneration in the Carotenoids in Age-Related Eye Disease Study 2 (CAREDS2), An Ancillary Study of the Women's Health Initiative
Creators: Tyler Etheridge - Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
Zhe Liu - Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
Marine Nalbandyan - Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
Spencer Cleland - Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
Barbara A Blodi - Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
Julie A Mares - Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
Steven Bailey - Oregon Health Sciences University Casey Eye Institute, Portland, OR, USA
Robert Wallace - University of Iowa, College of Public Health, Department of Epidemiology, Iowa City, IA, USA
Karen Gehrs - University of Iowa, Department of Ophthalmology, University of Iowa, Iowa City, IA, USA
Lesley F Tinker - Cancer Research Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Ronald Gangnon - Department of Biostatistics & Medical Informatics, University of Wisconsin-Madison, Madison, WI, USA
Amitha Domalpally - Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
CAREDS2 Research Study Group
Resource Type: Journal article
Publication Details: Translational vision science & technology, Vol.10(2), pp.39-14
DOI: 10.1167/tvst.10.2.39
PMID: 34003924
NLM abbreviation: Transl Vis Sci Technol
ISSN: 2164-2591
eISSN: 2164-2591
Language: English
Date published: 02/05/2021
Academic Unit: Epidemiology; Injury Prevention Research Center; Internal Medicine; Ophthalmology and Visual Sciences
Record Identifier: 9984101222502771

Metrics

27 Record Views

12 Times Cited - Web of Science