Journal article
Association of Myositis Autoantibodies, Clinical Features, and Environmental Exposures at Illness Onset with Disease Course in Juvenile Myositis
Arthritis & rheumatology (Hoboken, N.J.), Vol.68(3), pp.761-768
03/01/2016
DOI: 10.1002/art.39466
PMID: 26474155
Abstract
Objective To identify early factors associated with disease course in patients with juvenile idiopathic inflammatory myopathies (IIMs). Methods Univariable and multivariable multinomial logistic regression analyses were performed in a large juvenile IIM registry (n = 365) and included demographic characteristics, early clinical features, serum muscle enzyme levels, myositis autoantibodies, environmental exposures, and immunogenetic polymorphisms. Results Multivariable associations with chronic or polycyclic courses compared to a monocyclic course included myositis-specific autoantibodies (multinomial odds ratio [OR] 4.2 and 2.8, respectively), myositis-associated autoantibodies (multinomial OR 4.8 and 3.5), and a documented infection within 6 months of illness onset (multinomial OR 2.5 and 4.7). A higher overall clinical symptom score at diagnosis was associated with chronic or monocyclic courses compared to a polycyclic course. Furthermore, severe illness onset was associated with a chronic course compared to monocyclic or polycyclic courses (multinomial OR 2.1 and 2.6, respectively), while anti-p155/140 autoantibodies were associated with chronic or polycyclic courses compared to a monocyclic course (multinomial OR 3.9 and 2.3, respectively). Additional univariable associations of a chronic course compared to a monocyclic course included photosensitivity, V-sign or shawl sign rashes, and cuticular overgrowth (OR 2.2-3.2). The mean ultraviolet index and highest ultraviolet index in the month before diagnosis were associated with a chronic course compared to a polycyclic course in boys (OR 1.5 and 1.3), while residing in the Northwest was less frequently associated with a chronic course (OR 0.2). Conclusion Our findings indicate that myositis autoantibodies, in particular anti-p155/140, and a number of early clinical features and environmental exposures are associated with a chronic course in patients with juvenile IIM. These findings suggest that early factors, which are associated with poorer outcomes in juvenile IIM, can be identified.
Details
- Title: Subtitle
- Association of Myositis Autoantibodies, Clinical Features, and Environmental Exposures at Illness Onset with Disease Course in Juvenile Myositis
- Creators
- G. Esther A HabersAdam M HuberGulnara MamyrovaIra N TargoffTerrance P O'HanlonSharon AdamsJanardan P PandeyChantal BoonackerMarco Van BrusselFrederick W MillerAnnet Van Royen-KerkhofLisa G RiderChildhood Myositis Heterogeneity Study Group
- Contributors
- Scott A Vogelgesang (Contributor) - University of Iowa, Internal Medicine
- Resource Type
- Journal article
- Publication Details
- Arthritis & rheumatology (Hoboken, N.J.), Vol.68(3), pp.761-768
- DOI
- 10.1002/art.39466
- PMID
- 26474155
- ISSN
- 2326-5191
- eISSN
- 2326-5205
- Grant note
- name: Intramural Research Program of the National Institute of Environmental Health Sciences, NIH; name: Cure JM Foundation
- Language
- English
- Date published
- 03/01/2016
- Academic Unit
- Immunology; Internal Medicine; Ophthalmology and Visual Sciences
- Record Identifier
- 9984094404902771
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