Journal article
Association of Neighborhood Disadvantage with Short- and Long-Term Outcomes After Pancreatectomy for Pancreatic Ductal Adenocarcinoma
Annals of surgical oncology, Vol.31(1), pp.488-498
01/2024
DOI: 10.1245/s10434-023-14347-w
PMCID: PMC11170687
PMID: 37782415
Abstract
While lower socioeconomic status has been shown to correlate with worse outcomes in cancer care, data correlating neighborhood-level metrics with outcomes are scarce. We aim to explore the association between neighborhood disadvantage and both short- and long-term postoperative outcomes in patients undergoing pancreatectomy for pancreatic ductal adenocarcinoma (PDAC).
We retrospectively analyzed 243 patients who underwent resection for PDAC at a single institution between 1 January 2010 and 15 September 2021. To measure neighborhood disadvantage, the cohort was divided into tertiles by Area Deprivation Index (ADI). Short-term outcomes of interest were minor complications, major complications, unplanned readmission within 30 days, prolonged hospitalization, and delayed gastric emptying (DGE). The long-term outcome of interest was overall survival. Logistic regression was used to test short-term outcomes; Cox proportional hazards models and Kaplan-Meier method were used for long-term outcomes.
The median ADI of the cohort was 49 (IQR 32-64.5). On adjusted analysis, the high-ADI group demonstrated greater odds of suffering a major complication (odds ratio [OR], 2.78; 95% confidence interval [CI], 1.26-6.40; p = 0.01) and of an unplanned readmission (OR, 3.09; 95% CI, 1.16-9.28; p = 0.03) compared with the low-ADI group. There were no significant differences between groups in the odds of minor complications, prolonged hospitalization, or DGE (all p > 0.05). High ADI did not confer an increased hazard of death (p = 0.63).
We found that worse neighborhood disadvantage is associated with a higher risk of major complication and unplanned readmission after pancreatectomy for PDAC.
Details
- Title: Subtitle
- Association of Neighborhood Disadvantage with Short- and Long-Term Outcomes After Pancreatectomy for Pancreatic Ductal Adenocarcinoma
- Creators
- Clayton T Marcinak - University of Wisconsin–MadisonCorinne E Praska - University of Wisconsin–MadisonRoberto J Vidri - University of Wisconsin–MadisonAmy K Taylor - University of Wisconsin–MadisonJohn K Krebsbach - University of Wisconsin–MadisonKaleem S Ahmed - University of Wisconsin–MadisonNoelle K LoConte - University of Wisconsin–MadisonPatrick R Varley - University of Wisconsin–MadisonMajid Afshar - University of Wisconsin–MadisonSharon M Weber - University of Wisconsin–MadisonDaniel E Abbott - University of Wisconsin–MadisonJomol Mathew - University of Wisconsin–MadisonMuhammed Murtaza - University of Wisconsin–MadisonMark E Burkard - University of Wisconsin–MadisonMatthew M Churpek - University of Wisconsin–MadisonSyed Nabeel Zafar - University of Wisconsin–Madison
- Resource Type
- Journal article
- Publication Details
- Annals of surgical oncology, Vol.31(1), pp.488-498
- DOI
- 10.1245/s10434-023-14347-w
- PMID
- 37782415
- PMCID
- PMC11170687
- NLM abbreviation
- Ann Surg Oncol
- ISSN
- 1068-9265
- eISSN
- 1534-4681
- Grant note
- P30 CA014520-48S4 / NCI NIH HHS R01 HL157262 / NHLBI NIH HHS T32 HG002760 / NHGRI NIH HHS P30 CA014520 / NCI NIH HHS R01 GM141068 / NIGMS NIH HHS U01 CA243078 / NCI NIH HHS UH2 CA234306 / NCI NIH HHS R01 CA223481 / NCI NIH HHS R01 CA234904 / NCI NIH HHS
- Language
- English
- Date published
- 01/2024
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984701258802771
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