Association of Paternal Age and Risk for Major Congenital Anomalies From the National Birth Defects Prevention Study, 1997 to 2004

Ridgely Fisk Green; Owen Devine; Krista S Crider; Richard S Olney; Natalie Archer; Andrew F Olshan; Stuart K Shapira; National Birth Defects Prevention Study

doi:10.1016/j.annepidem.2009.10.009

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Association of Paternal Age and Risk for Major Congenital Anomalies From the National Birth Defects Prevention Study, 1997 to 2004

Journal article

Peer reviewed

Association of Paternal Age and Risk for Major Congenital Anomalies From the National Birth Defects Prevention Study, 1997 to 2004

Ridgely Fisk Green, Owen Devine, Krista S Crider, Richard S Olney, Natalie Archer, Andrew F Olshan, Stuart K Shapira and National Birth Defects Prevention Study

Annals of epidemiology, Vol.20(3), pp.241-249

2010

DOI: 10.1016/j.annepidem.2009.10.009

PMCID: PMC2824069

PMID: 20056435

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Abstract

The objective of this study was to examine the associations between paternal age and birth defects of unknown etiologies while carefully controlling for maternal age. By using 1997 to 2004 data from the National Birth Defects Prevention Study, we fit logistic regression models with paternal and maternal age as continuous variables while adjusting for demographic and other factors. Elevated odds ratios (ORs) for each year increase in paternal age were found for cleft palate (OR. 1.02, 95% confidence interval [95% CI], 1.00–1.04), diaphragmatic hernia (OR, 1.04; 95% CI, 1.02–1.06), right ventricular outflow tract obstruction (OR, 1.03; 95% CI, 1.01–1.04), and pulmonary valve stenosis (OR, 1.02, 95% CI, 1.01–1.04). At younger paternal ages, each year increase in paternal age correlated with increased odds of having offspring with encephalocele, cataract, esophageal atresia, anomalous pulmonary venous return, and coarctation of the aorta, but these increased odds were not observed at older paternal ages. The effect of paternal age was modified by maternal age for gastroschisis, omphalocele, spina bifida, all orofacial clefts, and septal heart defects. Our findings suggest that paternal age may be a risk factor for some multifactorial birth defects.

Congenital Abnormalities

Maternal Age

Paternal Age

Risk Factors

Details

Title: Subtitle: Association of Paternal Age and Risk for Major Congenital Anomalies From the National Birth Defects Prevention Study, 1997 to 2004
Creators: Ridgely Fisk Green - National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA
Owen Devine - National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA
Krista S Crider - National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA
Richard S Olney - National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA
Natalie Archer - Texas Department of State Health Services, Austin, TX
Andrew F Olshan - Department of Epidemiology, University of North Carolina, Chapel Hill, NC
Stuart K Shapira - National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA
National Birth Defects Prevention Study
Contributors: Paul A Romitti (Contributor) - University of Iowa, Epidemiology
Resource Type: Journal article
Publication Details: Annals of epidemiology, Vol.20(3), pp.241-249
DOI: 10.1016/j.annepidem.2009.10.009
PMID: 20056435
PMCID: PMC2824069
NLM abbreviation: Ann Epidemiol
ISSN: 1047-2797
eISSN: 1873-2585
Publisher: Elsevier Inc
Grant note: P30ES10126 / National Institute of Environmental Health Sciences
Language: English
Date published: 2010
Academic Unit: Epidemiology; Biostatistics
Record Identifier: 9984214678402771

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