Journal article
Association of Plasma Magnesium with Prediabetes and Type 2 Diabetes Mellitus in Adults
Scientific reports, Vol.7(1), 12763
10/06/2017
DOI: 10.1038/s41598-017-13050-7
PMCID: PMC5630593
PMID: 28986547
Abstract
Our study aimed to assess the associations of plasma magnesium with prediabetes and type 2 diabetes (T2D) among Chinese adults. We conducted a case-control analysis of 4447 participants: 867 newly diagnosed prediabetes patients, 1475 newly diagnosed T2D patients and 2105 normal glucose tolerance (NGT) individuals. In a subsample of 599 apparently healthy individuals, we measured plasma hs-CRP levels to examine their relation to plasma magnesium. Plasma magnesium and hs-CRP were measured by inductively coupled plasma mass spectrometry and an enzyme-linked immunosorbent assay, respectively. Plasma magnesium decreased from NGT to prediabetes to T2D, and was inversely associated with prediabetes and T2D. After adjustment for potential confounding factors, the ORs from the lowest to highest quartiles of plasma magnesium were 1, 0.57 (95%CI, 0.44-0.74), 0.49 (0.37-0.65) and 0.51 (0.37-0.70) for prediabetes, and 1, 0.26 (0.20-0.33), 0.15 (0.12-0.20) and 0.15 (0.11-0.20) for T2D. Consistently, plasma magnesium was inversely correlated with plasma hs-CRP in our subsample analysis; the geometric mean hs-CRP concentration for ascending quartiles of plasma magnesium were 1.29 (1.06-1.57), 1.16 (0.95-1.41), 1.00 (0.81-1.22), and 0.71 (0.58-0.88) mg/l. Plasma magnesium was independently and inversely associated with prediabetes and T2D in Chinese adults.
Details
- Title: Subtitle
- Association of Plasma Magnesium with Prediabetes and Type 2 Diabetes Mellitus in Adults
- Creators
- Sijing Chen - Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, ChinaXiaoling Jin - Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, ChinaJun Liu - Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, ChinaTaoping Sun - Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, ChinaManling Xie - Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, ChinaWei Bao - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA, 52242, USAXuefeng Yu - Division of Endocrinology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, ChinaXuefeng Yang - Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, ChinaYan Zhang - Hubei Provincial Key Laboratory of Yeast Function, Yichang, 443003, ChinaHaibo Zhang - Hubei Provincial Key Laboratory of Yeast Function, Yichang, 443003, ChinaZhilei Shan - Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. shanzhilei3118@126.comLiegang Liu - Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. lgliu@mails.tjmu.edu.cn
- Resource Type
- Journal article
- Publication Details
- Scientific reports, Vol.7(1), 12763
- DOI
- 10.1038/s41598-017-13050-7
- PMID
- 28986547
- PMCID
- PMC5630593
- NLM abbreviation
- Sci Rep
- ISSN
- 2045-2322
- eISSN
- 2045-2322
- Publisher
- England
- Grant note
- P30 ES005605 / NIEHS NIH HHS
- Language
- English
- Date published
- 10/06/2017
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9983995012602771
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