Journal article
Association of RGS2 Gene Polymorphisms with Suicide and Increased RGS2 Immunoreactivity in the Postmortem Brain of Suicide Victims
Neuropsychopharmacology (New York, N.Y.), Vol.33(7), pp.1537-1544
2008
DOI: 10.1038/sj.npp.1301557
PMID: 17728697
Abstract
Regulators of G-protein signaling are a family of proteins that negatively regulate the intracellular signaling of G protein-coupled receptors, such as the serotonin receptor. Recent studies have suggested that one of these proteins, the regulator of G-protein signaling 2 (RGS2), plays an important part in anxiety and/or aggressive behavior. To explore the involvement of the RGS2 gene in the vulnerability to suicide, we screened Japanese suicide victims for sequence variations in the RGS2 gene and carried out an association study of RGS2 gene polymorphisms with suicide victims. In the eight identified polymorphisms that were identified by mutation screening, we genotyped four common single-nucleotide polymorphisms (SNPs) in the RGS2 gene, and found significant differences in the distribution of the SNP3 (C+2971G, rs4606) genotypes and alleles of the SNP2 (C-395G, rs2746072) and the SNP3 between completed suicides and the controls. The distribution of the haplotype was also significantly different between the two groups (global p<0.0001). Furthermore, RGS2 immunoreactivity significantly increased in the amygdala and the prefrontal cortex (Brodmann area 9 (BA9)) of the postmortem brain of the suicide subjects. These findings suggest that RGS2 is genetically involved in the biological susceptibility to suicide in the Japanese population.
Details
- Title: Subtitle
- Association of RGS2 Gene Polymorphisms with Suicide and Increased RGS2 Immunoreactivity in the Postmortem Brain of Suicide Victims
- Creators
- Huxing Cui - Department of Psychiatry and Neurology, Kobe University Graduate School of Medicine, Kobe, JapanNaoki NISHIGUCHI - Department of Psychiatry and Neurology, Kobe University Graduate School of Medicine, Kobe, JapanElena IVLEVA - Department of Psychiatry and Neurology, Kobe University Graduate School of Medicine, Kobe, JapanMasaya YANAGI - Department of Psychiatry and Neurology, Kobe University Graduate School of Medicine, Kobe, JapanMasaaki FUKUTAKE - Department of Psychiatry and Neurology, Kobe University Graduate School of Medicine, Kobe, JapanHideyuki NUSHIDA - Department of Legal Medicine, Kobe University Graduate School of Medicine, Kobe, JapanYasuhiro UENO - Department of Legal Medicine, Kobe University Graduate School of Medicine, Kobe, JapanNoboru KITAMURA - Department of Psychiatry and Neurology, Kobe General City Hospital, Kobe, JapanKiyoshi MAEDA - Department of Psychiatry and Neurology, Kobe University Graduate School of Medicine, Kobe, JapanOsamu SHIRAKAWA - Department of Psychiatry and Neurology, Kobe University Graduate School of Medicine, Kobe, Japan
- Resource Type
- Journal article
- Publication Details
- Neuropsychopharmacology (New York, N.Y.), Vol.33(7), pp.1537-1544
- Publisher
- Nature Publishing; New York, NY
- DOI
- 10.1038/sj.npp.1301557
- PMID
- 17728697
- ISSN
- 0893-133X
- eISSN
- 1740-634X
- Language
- English
- Date published
- 2008
- Academic Unit
- Neuroscience and Pharmacology
- Record Identifier
- 9984040475702771
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