Journal article
Association of Serum Low-Density Lipoprotein, High-Density Lipoprotein, and Total Cholesterol With Development of Knee Osteoarthritis
Arthritis care & research (2010), Vol.74(2), pp.274-280
02/2022
DOI: 10.1002/acr.24455
PMCID: PMC8054264
PMID: 32961029
Abstract
Studies suggest an association between elevated total serum cholesterol, particularly low-density lipoprotein (LDL), and osteoarthritis (OA). The present study was undertaken to evaluate the association between total cholesterol, LDL, and high-density lipoprotein (HDL) and risk of knee OA.
We studied participants from the Multicenter Osteoarthritis study (MOST) cohort at risk of developing knee OA. From baseline through 7 years, repeated knee radiographs and magnetic resonance images (MRIs) were obtained, and knee symptoms were queried. From baseline fasting blood samples, lipids and lipoproteins were analyzed using standard assays. After excluding participants with baseline OA, we defined 2 sets of patients: those developing radiographic OA, and those developing symptomatic OA (knee pain and radiographic OA). Controls did not develop these outcomes. Additionally, we examined worsening of cartilage loss and synovitis on MRI and of knee pain using the Western Ontario and McMaster Universities Osteoarthritis Index scale. We carried out logistic regression adjusting for age, sex, body mass index, education, baseline pain, and depressive symptoms, testing total cholesterol and lipoproteins as continuous measures, and we performed sensitivity analyses examining whether commonly used thresholds for high cholesterol, LDL, or low HDL increased risk.
We studied 337 patients with incident symptomatic OA and 283 patients with incident radiographic OA. The mean age at baseline was 62 years (55% women). Neither total cholesterol, LDL, nor HDL showed a significant association with radiographic or symptomatic OA. Additionally, we found no association of these lipid measures with cartilage loss, worsening synovitis, or worsening knee pain.
Our data do not support an association between total cholesterol, LDL, or HDL with OA outcomes.
Details
- Title: Subtitle
- Association of Serum Low-Density Lipoprotein, High-Density Lipoprotein, and Total Cholesterol With Development of Knee Osteoarthritis
- Creators
- Jessica L Schwager - Boston University, Boston, MassachusettsMichael C Nevitt - University of California, San FranciscoJames Torner - University of Iowa, Iowa CityCora E Lewis - University of Alabama at BirminghamNirupa R Matthan - Tufts University, Medford, MassachusettsNa Wang - Boston University, Boston, MassachusettsXianbang Sun - Boston University, Boston, MassachusettsAlice H Lichtenstein - Tufts University, Medford, MassachusettsDavid Felson - Boston University, Boston, Massachusetts, and University of Manchester Centre for Epidemiology, and the National Institute for Health Research Manchester Biomedical Research Centre, Manchester University NHS Trust, Manchester, UKMulticenter Osteoarthritis Study Group
- Resource Type
- Journal article
- Publication Details
- Arthritis care & research (2010), Vol.74(2), pp.274-280
- DOI
- 10.1002/acr.24455
- PMID
- 32961029
- PMCID
- PMC8054264
- NLM abbreviation
- Arthritis Care Res (Hoboken)
- ISSN
- 2151-464X
- eISSN
- 2151-4658
- Grant note
- U01 AG018947 / NIA NIH HHS U01 AG018832 / NIA NIH HHS P30 AR072571 / NIAMS NIH HHS R01-AR-071950 / NIH HHS U01-AG-19069 / NIH HHS U01 AG019069 / NIA NIH HHS U01-AG-18820 / NIH HHS U01-AG-18947 / NIH HHS R01 AR071950 / NIAMS NIH HHS P30-AR-072571 / NIH HHS U01-AG-18832 / NIH HHS NIHR U01 AG018820 / NIA NIH HHS
- Language
- English
- Date published
- 02/2022
- Academic Unit
- Epidemiology; Surgery; Injury Prevention Research Center; Neurosurgery
- Record Identifier
- 9984214853202771
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