Journal article
Association of Serum Uric Acid With All-Cause and Cardiovascular Mortality in Diabetes
Diabetes care, Vol.46(2), pp.425-433
02/01/2023
DOI: 10.2337/dc22-1339
PMID: 36490263
Abstract
To investigate whether serum uric acid (SUA) level is associated with all-cause and cardiovascular disease (CVD) mortality among individuals with diabetes.
In this prospective cohort study, we included patients with diabetes from the U.S. National Health and Nutritional Examination Survey (NHANES) 1999-2018. Mortality and underlying causes of death were ascertained by linkage to national death records through 31 December 2019. Weighted Cox proportional hazards regression models were used to evaluate hazard ratios (HRs) and 95% CIs for all-cause and CVD mortality. We also performed a meta-analysis of available cohort studies to combine the association between SUA level and mortality in diabetes.
Among the 7,101 patients with diabetes from NHANES 1999-2018, the weighted mean of SUA level was 5.7 mg/dL. During 57,926 person-years of follow-up, 1,900 deaths (n = 674 deaths from CVD) occurred. In the fully adjusted model, when compared with patients with diabetes in the lowest SUA quintile, those in the highest SUA quintile had the HRs (95% CIs) of 1.28 (1.03, 1.58) for all-cause mortality and 1.41 (1.03, 1.94) for CVD mortality. We included 13 cohort studies in the meta-analysis and found that the pooled HRs (95% CIs) were 1.08 (1.05, 1.11) for all-cause mortality and 1.05 (1.03, 1.06) for CVD mortality per 1 mg/dL increment of SUA level in patients with diabetes.
This study indicated that higher SUA levels were associated with increased risks of all-cause and CVD mortality in diabetes. Interventional studies are needed to elucidate the health effect of treatments to lower SUA levels.
Details
- Title: Subtitle
- Association of Serum Uric Acid With All-Cause and Cardiovascular Mortality in Diabetes
- Creators
- Benchao Li - Wuhan University of Science and TechnologyLiangkai Chen - Huazhong University of Science and TechnologyXueting Hu - Huazhong University of Science and TechnologyTing Tan - Wuhan University of Science and TechnologyJiajia Yang - Wuhan University of Science and TechnologyWei Bao - University of Science and Technology of ChinaShuang Rong - Wuhan University of Science and Technology
- Resource Type
- Journal article
- Publication Details
- Diabetes care, Vol.46(2), pp.425-433
- DOI
- 10.2337/dc22-1339
- PMID
- 36490263
- ISSN
- 0149-5992
- eISSN
- 1935-5548
- Language
- English
- Date published
- 02/01/2023
- Academic Unit
- Epidemiology
- Record Identifier
- 9984363664402771
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