Association of Single Nucleotide Polymorphisms in a Glutamate Receptor Gene (GRM8) with Theta Power of Event-Related Oscillations and Alcohol Dependence

Andrew C. H Chen; Yongqiang Tang; Madhavi Rangaswamy; Jen C Wang; Laura Almasy; Tatiana Foroud; Howard J Edenberg; Victor Hesselbrock; John Nurnberger; Samuel Kuperman; Sean J O'Connor; Marc A Schuckit; Lance O Bauer; Jay Tischfield; John P Rice; Laura Bierut; Alison Goate; Bernice Porjesz

doi:10.1002/ajmg.b.30818

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Association of Single Nucleotide Polymorphisms in a Glutamate Receptor Gene (GRM8) with Theta Power of Event-Related Oscillations and Alcohol Dependence

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Association of Single Nucleotide Polymorphisms in a Glutamate Receptor Gene (GRM8) with Theta Power of Event-Related Oscillations and Alcohol Dependence

Andrew C. H Chen, Yongqiang Tang, Madhavi Rangaswamy, Jen C Wang, Laura Almasy, Tatiana Foroud, Howard J Edenberg, Victor Hesselbrock, John Nurnberger, Samuel Kuperman, …

American journal of medical genetics. Part B, Neuropsychiatric genetics, Vol.150B(3), pp.359-368

04/05/2009

DOI: 10.1002/ajmg.b.30818

PMCID: PMC2660384

PMID: 18618593

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https://soar.suny.edu/bitstream/20.500.12648/8209/1/nihms64447.pdfView

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Abstract

Evidence suggests the P3 amplitude of the event-related potential and its underlying superimposed event-related oscillations (EROs), primarily in the theta (4–5 Hz) and delta (1–3 Hz) frequencies, as endophenotypes for the risk of alcoholism and other disinhibitory disorders. Major neurochemical substrates contributing to theta and delta rhythms and P3 involve strong GABAergic, cholinergic and glutamatergic system interactions. The aim of this study was to test the potential associations between single nucleotide polymorphisms (SNPs) in glutamate receptor genes and ERO quantitative traits.

Disinhibition

Alcohol dependence

mGluR8

Endophenotype

Details

Title: Subtitle: Association of Single Nucleotide Polymorphisms in a Glutamate Receptor Gene (GRM8) with Theta Power of Event-Related Oscillations and Alcohol Dependence
Creators: Andrew C. H Chen
Yongqiang Tang
Madhavi Rangaswamy
Jen C Wang
Laura Almasy
Tatiana Foroud
Howard J Edenberg
Victor Hesselbrock
John Nurnberger
Samuel Kuperman
Sean J O'Connor - Indiana University School of Medicine
Marc A Schuckit
Lance O Bauer
Jay Tischfield
John P Rice
Laura Bierut
Alison Goate
Bernice Porjesz
Resource Type: Journal article
Publication Details: American journal of medical genetics. Part B, Neuropsychiatric genetics, Vol.150B(3), pp.359-368
DOI: 10.1002/ajmg.b.30818
PMID: 18618593
PMCID: PMC2660384
NLM abbreviation: Am J Med Genet B Neuropsychiatr Genet
ISSN: 1552-4841
eISSN: 1552-485X
Language: English
Date published: 04/05/2009
Academic Unit: Psychiatry; Stead Family Department of Pediatrics
Record Identifier: 9984004085702771

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