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Association of Sleep With Risk of Alzheimer's Disease Mortality: NIH-AARP Diet and Health Study
Journal article   Open access   Peer reviewed

Association of Sleep With Risk of Alzheimer's Disease Mortality: NIH-AARP Diet and Health Study

Aaron C Schneider, Chooza Moon, Kara Whitaker, Dong Zhang, Lucas J Carr, Wei Bao and Qian Xiao
Journal of applied gerontology, Vol.41(4), pp.1057-1065
04/01/2022
DOI: 10.1177/07334648211019207
PMCID: PMC9131728
PMID: 34109847
url
https://www.ncbi.nlm.nih.gov/pmc/articles/9131728View
Open Access

Abstract

Objectives: Alzheimer's disease (AD) and related dementias contribute to one in three senior deaths. Lifestyle factors, including sleep, may contribute to AD risk and mortality; however, current evidence on sleep and AD mortality is mixed. Methods: We used data from the NIH-AARP Diet and Health Study. Sleep duration and napping were self-reported and AD death were ascertained via linkage to the National Death Index. Results: Long sleep and napping were both associated with increased AD mortality. Specifically, 9+ hr of sleep was associated with 50% increase (hazard ratio = 1.50, 95% CI = [1.17, 1.92]) in AD mortality when compared 7 to 8 hr, while napping for 1+ hr was associated with 29% increase (1.29 [1.08, 1.55]) when compared with no napping. Results appeared to be stronger in men and remained after removing AD deaths within first 5 years after baseline. Discussion: Long sleep and napping may predict higher AD mortality in the older population.
 Geriatrics & Gerontology Gerontology Life Sciences & Biomedicine Science & Technology

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