Journal article
Association of Statin Use With Disability-Free Survival and Cardiovascular Disease Among Healthy Older Adults
Journal of the American College of Cardiology, Vol.76(1), pp.17-27
07/07/2020
DOI: 10.1016/j.jacc.2020.05.016
PMCID: PMC7967891
PMID: 32616158
Abstract
BACKGROUND There is clinical uncertainty regarding the benefits and harms of prescribing statins in healthy subjects >= 70 years of age.
OBJECTIVES The aim of this study was to examine the association among statins, dementia-free and disability-free survival, and cardiovascular disease (CVD) among healthy older adults using data from the ASPREE (Aspirin in Reducing Events in the Elderly) trial.
METHODS ASPREE was a randomized trial of 19,114 community-dwelling persons in Australia and the United States >= 65 years of age and free of documented CVD, dementia, and disability. Data were collected for those >= 70 years of age, and participants who took statins at baseline were compared with those who did not using Cox proportional hazards regression with inverse probability weighting. The primary outcome, referred to as "disability-free survival," was a composite of all-cause mortality, dementia, or persistent physical disability. Other outcomes included the individual components of the composite outcome, major adverse cardiovascular events, fatal CVD, myocardial infarction, and stroke.
RESULTS Of the 18,096 included participants (median age 74.2 years, 56.0% women), 5,629 took statins at baseline. Over a median follow-up period of 4.7 years, baseline statin use was not associated with disability-free survival or with the risk for all-cause mortality or dementia. However, it was associated with lower risks for physical disability and all cardiovascular outcomes.
CONCLUSIONS Among healthy community-dwelling adults >= 70 years of age, statin use may be beneficial for preventing physical disability and CVD but not beneficial for prolonging disability-free survival or avoiding death or dementia. Future clinical trials are needed to confirm these findings. (C) 2020 by the American College of Cardiology Foundation.
Details
- Title: Subtitle
- Association of Statin Use With Disability-Free Survival and Cardiovascular Disease Among Healthy Older Adults
- Creators
- Zhen Zhou - Menzies Research InstituteRichard Ofori-Asenso - Monash UniversityAndrea J. Curtis - Monash UniversityMonique Breslin - Menzies Research InstituteRory Wolfe - Monash UniversityJohn J. McNeil - Monash UniversityAnne M. Murray - Berman Center for Outcomes and Clinical ResearchMichael E. Ernst - Roy J. and Lucille A. Carver College of MedicineChristopher M. Reid - Curtin UniversityJessica E. Lockery - Monash UniversityRobyn L. Woods - Monash UniversityAndrew M. Tonkin - Monash UniversityMark R. Nelson - Menzies Research Institute
- Resource Type
- Journal article
- Publication Details
- Journal of the American College of Cardiology, Vol.76(1), pp.17-27
- Publisher
- Elsevier
- DOI
- 10.1016/j.jacc.2020.05.016
- PMID
- 32616158
- PMCID
- PMC7967891
- ISSN
- 0735-1097
- eISSN
- 1558-3597
- Number of pages
- 11
- Grant note
- 334047; 1127060 / National Health and Medical Research Council (NHMRC) of Australia Pfizer National Cancer Institute at the National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) National Health and Medical Research Council; National Health and Medical Research Council (NHMRC) of Australia U01AG029824 / National Institute on Aging; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) Merck; Merck & Company Victorian Cancer Agency Amgen NHMRC Principal Research Fellowship; National Health and Medical Research Council (NHMRC) of Australia NHMRC; National Health and Medical Research Council (NHMRC) of Australia Monash University
- Language
- English
- Date published
- 07/07/2020
- Academic Unit
- Family and Community Medicine; Pharmacy Practice and Science
- Record Identifier
- 9984297452402771
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