Association of Systemic Inflammation with Depressive Symptoms in Individuals with COPD

Hilary C Strollo; Seyed M Nouraie; Karin F Hoth; Craig M Riley; Chad Karoleski; Yingze Zhang; Nicola A Hanania; Russell P Bowler; Jessica Bon; Frank C Sciurba

doi:10.2147/COPD.S322144

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Association of Systemic Inflammation with Depressive Symptoms in Individuals with COPD

Journal article

Open access

Association of Systemic Inflammation with Depressive Symptoms in Individuals with COPD

Hilary C Strollo, Seyed M Nouraie, Karin F Hoth, Craig M Riley, Chad Karoleski, Yingze Zhang, Nicola A Hanania, Russell P Bowler, Jessica Bon and Frank C Sciurba

International journal of chronic obstructive pulmonary disease, Vol.16, pp.2515-2522

2021

DOI: 10.2147/COPD.S322144

PMCID: PMC8423410

PMID: 34511896

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Abstract

Depression is a prevalent comorbidity of chronic obstructive pulmonary disease (COPD) that, along with COPD, has been associated with inflammation. An association between inflammation and depression in COPD has not been validated in a large COPD cohort. Individuals from the University of Pittsburgh SCCOR cohort and the COPDGene cohort with tobacco use history and airway obstruction (FEV /FVC <0.7) were evaluated using the Beck Depression Inventory II (BDI-II) and the Hospital Anxiety and Depression Scale (HADS), respectively. Participants completed symptom-related questionnaires and plasma IL-6 measurements. -test, Fisher's Exact tests and logistic regression were used for statistical analysis. The SCCOR cohort included 220 obstructed participants: 44% female and 21.4% with elevated depressive symptoms. GOLD staging distribution was predominantly stage I and II. The COPDGene cohort included 745 obstructed participants: 44% female and 13.0% with elevated depressive symptoms. GOLD distribution was predominantly stage II and III. In the SCCOR cohort, correlation between IL-6 and depressive symptoms trended toward significance (p= 0.08). Multivariable modeling adjusted for FEV , age, gender and medical comorbidities showed a significant association (OR = 1.70, 95% CI = 1.08-2.69). IL-6 was significantly associated with elevated depressive symptoms in COPDGene in both univariate (p=0.001) and multivariable modeling (OR = 1.52, 95% CI =1.13-2.04). Elevated plasma IL-6 levels are associated with depressive symptoms in individuals with COPD independent of airflow limitation and comorbid risk factors for depression. Our results suggest that systemic inflammation may play a significant and possibly bidirectional role in depression associated with COPD.

Cohort Studies

Comorbidity

Depression - diagnosis

Depression - epidemiology

Female

Humans

Inflammation - diagnosis

Inflammation - epidemiology

Male

Pulmonary Disease, Chronic Obstructive - diagnosis

Pulmonary Disease, Chronic Obstructive - epidemiology

Details

Title: Subtitle: Association of Systemic Inflammation with Depressive Symptoms in Individuals with COPD
Creators: Hilary C Strollo - University of Pittsburgh Medical Center
Seyed M Nouraie - University of Pittsburgh Medical Center
Karin F Hoth - University of Iowa
Craig M Riley - Chester County Hospital
Chad Karoleski - University of Pittsburgh Medical Center
Yingze Zhang - University of Pittsburgh Medical Center
Nicola A Hanania - Baylor College of Medicine
Russell P Bowler - National Jewish Health
Jessica Bon - University of Pittsburgh Medical Center
Frank C Sciurba - University of Pittsburgh Medical Center
Resource Type: Journal article
Publication Details: International journal of chronic obstructive pulmonary disease, Vol.16, pp.2515-2522
DOI: 10.2147/COPD.S322144
PMID: 34511896
PMCID: PMC8423410
NLM abbreviation: Int J Chron Obstruct Pulmon Dis
ISSN: 1176-9106
eISSN: 1178-2005
Grant note: T32 HL007563 / NHLBI NIH HHS U01 HL089897 / NHLBI NIH HHS P50 HL084948 / NHLBI NIH HHS
Language: English
Date published: 2021
Academic Unit: Psychiatry; Iowa Neuroscience Institute
Record Identifier: 9984293756402771

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