Journal article
Association of Uric Acid With Vascular Stiffness in the Framingham Heart Study
American journal of hypertension, Vol.28(7), pp.877-883
07/2015
DOI: 10.1093/ajh/hpu253
PMCID: PMC4542908
PMID: 25552515
Abstract
Uric acid is associated with increased risk of cardiovascular disease and arterial stiffness in patients with hypertension or stroke. It remains unknown if uric acid is associated with arterial stiffness in the general population.
We analyzed the association between serum uric acid levels and measures of arterial stiffness such as carotid-femoral pulse wave velocity (CF PWV), carotid-radial pulse wave velocity (CR PWV) and augmentation index (AI) in 4,140 participants from the Generation 3 Framingham cohort using linear regression.
Mean (SD) age was 40.0 (8.8) years and mean (SD) serum uric acid levels were 5.3 (1.5) mg/dl. Mean (SD) CF PWV was 7.0 (1.4) m/s. Individuals in the highest quartile of uric acid were more likely to be male, have a higher prevalence of hypertension, higher BMI, fasting glucose and insulin, and lower estimated glomerular filtration rate (eGFR). Multivariate adjusted means of CF PWV were 6.90, 6.94, 7.06, and 7.15 m/s for uric acid quartile 1, 2, 3, and 4 respectively. In unadjusted analysis each 1mg/dl increase in uric acid was associated with higher CF-PWV (β = 0.27; 95% CI = 0.25, 0.29; P < 0.0001). This was attenuated but remained significant after adjusting for age, sex, smoking, hypertension, BMI, fasting glucose, insulin, animal protein intake, and eGFR (β= 0.06; 95% CI = 0.02, 0.09; P < 0.0007). There was no association between serum uric acid levels and AI upon adjustment for cardiovascular risk factors.
Serum uric acid levels are significantly associated with CF PWV and CR PWV in a younger Caucasian population.
Details
- Title: Subtitle
- Association of Uric Acid With Vascular Stiffness in the Framingham Heart Study
- Creators
- Tapan Mehta - Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Center, Aurora, CO, USA; Tapan.mehta@ucdenver.eduEugene Nuccio - Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Center, Aurora, CO, USAKim McFann - Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Center, Aurora, CO, USAMagdalena Madero - Department of Medicine, Division of Nephrology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico, MexicoMark J Sarnak - Department of Medicine, Division of Nephrology, Tufts Medical Center, Boston, MA, USADiana Jalal - Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Center, Aurora, CO, USA
- Resource Type
- Journal article
- Publication Details
- American journal of hypertension, Vol.28(7), pp.877-883
- DOI
- 10.1093/ajh/hpu253
- PMID
- 25552515
- PMCID
- PMC4542908
- ISSN
- 0895-7061
- eISSN
- 1879-1905
- Grant note
- R01 HL076784 / NHLBI NIH HHS N01HC25195 / NHLBI NIH HHS N01-HC-25195 / NHLBI NIH HHS K23 DK088833 / NIDDK NIH HHS R01 HL70100 / NHLBI NIH HHS 1R01AG028321 / NIA NIH HHS R01 HL070100 / NHLBI NIH HHS K24DK07820 / NIDDK NIH HHS 1K23DK088833 / NIDDK NIH HHS R01 AG028321 / NIA NIH HHS
- Language
- English
- Date published
- 07/2015
- Academic Unit
- Nephrology; Internal Medicine
- Record Identifier
- 9984094512602771
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